Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase

Oncotarget
Marta LualdiRoberto Taramelli

Abstract

As widely recognized, tumor growth entails a close and complex cross-talk among cancer cells and the surrounding tumor microenvironment. We recently described the human RNASET2 gene as one key player of such microenvironmental cross-talk. Indeed, the protein encoded by this gene is an extracellular RNase which is able to control cancer growth in a non-cell autonomous mode by inducing a sustained recruitment of immune-competent cells belonging to the monocyte/macrophage lineage within a growing tumor mass. Here, we asked whether this oncosuppressor gene is sensitive to stress challenges and whether it can trigger cell-intrinsic processes as well. Indeed, RNASET2 expression levels were consistently found to increase following stress induction. Moreover, changes in RNASET2 expression levels turned out to affect several cancer-related parameters in vitro in an ovarian cancer cell line model. Of note, a remarkable rearrangement of the actin cytoskeleton organization, together with changes in cell adhesion and motility, emerged as putative mechanisms by which such cell-autonomous role could occur. Altogether, these biological features allow to put forward the hypothesis that the RNASET2 protein can act as a molecular barrier for limi...Continue Reading

References

Sep 7, 2004·Carcinogenesis·Adrian Harold Box, Douglas James Demetrick
Jun 16, 2005·Current Opinion in Immunology·Joost J Oppenheim, De Yang
Apr 20, 2006·Archives of Biochemistry and Biophysics·Paola CampomenosiRoberto Taramelli
Jun 17, 2006·Cell·Ivone Bruno, Miles F Wilkinson
Jun 12, 2008·Oncology Research·Laura MontiRoberto Taramelli
Aug 15, 2008·Cancer Research·Seth B Coffelt, Aline B Scandurro
Apr 1, 2009·The Journal of Cell Biology·Satoshi YamasakiPaul Anderson
Apr 1, 2009·The Journal of Cell Biology·Debrah M Thompson, Roy Parker
Jul 28, 2009·Cell·Debrah M Thompson, Roy Parker
Jul 29, 2009·The Journal of Experimental Medicine·Bart EvertsGabriele Schramm
Feb 11, 2010·Biochimica Et Biophysica Acta·Daphne H E W Huberts, Ida J van der Klei
Mar 2, 2010·Trends in Biochemical Sciences·Natalie Luhtala, Roy Parker
Jul 16, 2010·Critical Reviews in Oncology/hematology·Laura M S SeeberPaul J van Diest
Dec 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Francesco AcquatiRoberto Taramelli
Feb 11, 2011·Molecular Biology of the Cell·Yvonne Aratyn-SchausMargaret L Gardel
Oct 14, 2011·Viruses·Nicholas PolakowskiIsabelle Lemasson
Nov 4, 2011·Nature Reviews. Genetics·Eulàlia de NadalFrancesc Posas
Dec 23, 2011·Biology of the Cell·Laura VidalinoPaolo Macchi
Aug 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Olga V LeontievaMikhail V Blagosklonny
Oct 5, 2012·Cell Death & Disease·E K MarkertA Vazquez
May 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Francesco AcquatiRoberto Taramelli
Jun 21, 2013·Open Biology·Tea Vallenius

❮ Previous
Next ❯

Citations

Aug 27, 2016·International Journal of Molecular Sciences·Francesca RoggianiAntonella Tomassetti
May 7, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Miryam Chiara MalacarneEnrico Caruso
Mar 27, 2020·Frontiers in Immunology·Nicolò BaranziniAnnalisa Grimaldi
Aug 20, 2016·Nature Communications·Harvind S ChahalKavita Y Sarin
Jan 11, 2017·Cell and Tissue Research·Nicolò BaranziniAnnalisa Grimaldi
Nov 22, 2019·Frontiers in Immunology·Francesco AcquatiDouglas M Noonan
Nov 15, 2016·International Journal of Oncology·Giovanna TurconiFrancesco Acquati
Apr 16, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Miryam Chiara MalacarneEnrico Caruso
Jul 25, 2021·International Journal of Molecular Sciences·Sara MonaciAntonella Naldini

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
flow cytometry
FCS
environmental stress
PCR

Software Mentioned

ACTIBIND
TScratch
CellQuest

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.