Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration.

Frontiers in Immunology
Huating ChenBinghui Li

Abstract

Wound healing is a multi-step process that includes multiple cellular events such as cell proliferation, cell adhesion, and chemotactic response as well as cell apoptosis. Accumulating studies have documented the significance of stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor 4 (CXCR4) signaling in wound repair and regeneration. However, the molecular mechanism of regeneration is not clear. This review describes various types of tissue regeneration that CXCR4 participates in and how the efficiency of regeneration is increased by CXCR4 overexpression. It emphasizes the pleiotropic effects of CXCR4 in regeneration. By delving into the specific molecular mechanisms of CXCR4, we hope to provide a theoretical basis for tissue engineering and future regenerative medicine.

References

Apr 5, 1996·Science·E C Butcher, L J Picker
Feb 9, 1996·Cell·D A Lauffenburger, A F Horwitz
Aug 11, 1998·Immunity·S G WardJ Westwick
Feb 2, 1999·The EMBO Journal·F Sánchez-Madrid, M A del Pozo
Dec 2, 1999·Genes & Development·S R DattaM E Greenberg
Mar 29, 2001·Nature Immunology·B Moser, P Loetscher
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·N C OttosonY Shimizu
Nov 26, 2002·The Journal of Cell Biology·Catherine G GalbraithMichael P Sheetz
Mar 11, 2003·American Journal of Respiratory and Critical Care Medicine·Roderick J PhillipsRobert M Strieter
Aug 2, 2003·Journal of Cell Science·Sylvain Merlot, Richard A Firtel
Oct 23, 2003·The Biochemical Journal·Seng-Lai Tan, Peter J Parker
Dec 6, 2003·Science·Anne J RidleyAlan Rick Horwitz
May 5, 2004·The Journal of Biological Chemistry·Angela M FischerAvery August
Jun 10, 2004·Current Biology : CB·Aya TakesonoPamela L Schwartzberg
Jul 6, 2004·Nature Medicine·Daniel J CeradiniGeoffrey C Gurtner
Dec 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jaime ImitolaSamia J Khoury
Apr 21, 2005·Kidney International·Florian TögelChristof Westenfelder
Apr 22, 2005·Nature·Jérôme GrosChristophe Marcelle
Jul 30, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Evangelos DalakasJohn N Plevris
Jan 18, 2006·Trends in Immunology·Stephen G Ward
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Kyle R LegateReinhard Fässler
Feb 25, 2006·Nature Reviews. Immunology·Carl Nathan
Jun 8, 2006·Neoplasia : an International Journal for Oncology Research·Tobias EnglRoman A Blaheta
Jan 19, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Julie Sainz, Masataka Sata
Jan 19, 2008·Journal of Molecular and Cellular Cardiology·Dongsheng ZhangYigang Wang
May 23, 2009·Circulation Research·Marc S Penn
Dec 23, 2009·Nature Reviews. Molecular Cell Biology·Brian E Richardson, Ruth Lehmann
Dec 24, 2009·Nature Reviews. Cancer·Jay S Desgrosellier, David A Cheresh
May 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Beverly A Teicher, Simon P Fricker
May 26, 2010·Nature Reviews. Immunology·Oliver Soehnlein, Lennart Lindbom

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Cancer Immunology, Immunotherapy : CII
Crescenzo D'AlterioStefania Scala
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Chin-Sheng HungYu-Jia Chang
© 2021 Meta ULC. All rights reserved