Pleiotropic roles of formyl peptide receptors

Cytokine & Growth Factor Reviews
Yingying LeJ M Wang

Abstract

FPR and FPRL1 belong to the seven-transmembrane, G protein-coupled chemoattractant receptor superfamily. Because of their capacity to interact with bacterial chemotactic formylated peptides, these receptors are thought to play a role in host defense against microbial infection. Recently, a variety of novel agonists have been identified for these receptors, including several host-derived endogenous molecules that are involved in proinflammatory responses. Most notably is the use of FPRL1 by at least three amyloidogenic protein and peptide ligands, the serum amyloid A (SAA), the 42 amino acid form of beta amyloid (Abeta(42)), and the prion peptide PrP106-126, to chemoattract and activate human phagocytic leukocytes. These new findings have greatly expanded the functional scope of the formyl peptide receptors and call for more in-depth investigation of the role of these receptors in pathophysiological conditions.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E SchiffmannS M Wahl
Apr 30, 1992·Biochemical and Biophysical Research Communications·R D YeC G Cochrane
May 16, 1990·Biochemical and Biophysical Research Communications·F BoulayP Vignais
Aug 1, 1984·The Journal of Infectious Diseases·F H ValoneE J Goetzl
Jun 5, 1980·The New England Journal of Medicine·G G Glenner
Jan 1, 1982·The Journal of Experimental Medicine·H Carp
Jul 1, 1994·The Pediatric Infectious Disease Journal·J S Abramson, J G Wheeler
Jul 1, 1994·The Journal of Experimental Medicine·S FioreC N Serhan
Aug 1, 1993·Neurology·J RogersP Willson
Apr 8, 1993·Nature·G ForloniF Tagliavini
Jan 1, 1996·Journal of Receptor and Signal Transduction Research·M D DomalewskiL A Sklar
Mar 21, 1997·The Journal of Biological Chemistry·D D BrowningR D Ye
Mar 1, 1997·Neurology·W F StewartE J Metter
Mar 1, 1997·Journal of Molecular and Cellular Cardiology·M KeitokuK Shirato
Dec 31, 1997·Journal of Neuroimmunology·K A DzenkoJ S Pachter
Sep 3, 1998·The Journal of Biological Chemistry·K Wenzel-SeifertR Seifert

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Citations

Jul 1, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Hong-Seok HaHeui-Soo Kim
Oct 18, 2003·Biochemical Pharmacology·Yoe-Sik BaeSung Ho Ryu
Feb 21, 2003·Microbes and Infection·Santiago Partida-SánchezFrances E Lund
Oct 29, 2002·Trends in Immunology·Yingying LeJi Ming Wang
Jul 31, 2009·Journal of Medicinal Chemistry·Agostino CilibrizziMaria Paola Giovannoni
Nov 3, 2012·The Journal of Biological Chemistry·Jennifer H MadenspacherMichael B Fessler
Dec 30, 2004·The Journal of Experimental Medicine·Isabelle MigeotteDavid Communi
Jun 2, 2005·Journal of the National Cancer Institute·Ye ZhouJi Ming Wang
Dec 25, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maren RautenbergAndreas Peschel
Dec 23, 2006·Acta Pharmacologica Sinica·Seong-Ho JoYoe-Sik Bae
Jul 10, 2013·Annual Review of Microbiology·András N SpaanJos A G van Strijp
May 13, 2011·American Journal of Respiratory and Critical Care Medicine·Lukas DidonMagnus Nord
Mar 5, 2013·The Journal of Clinical Investigation·Keqiang ChenJi Ming Wang
Jan 27, 2009·BMC Immunology·Berardo de Jesus RodriguezHenri Salmon
Jun 1, 2004·Bioscience, Biotechnology, and Biochemistry·Takahiro Tsuruki, Masaaki Yoshikawa
Feb 1, 2003·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Yoshitaka KumonKozo Hashimoto
Jan 23, 2016·Cytokine & Growth Factor Reviews·Mieke De BuckJo Van Damme
Jan 13, 2015·International Immunopharmacology·Mariana C SouzaMaria G Henriques
May 23, 2012·Cytokine & Growth Factor Reviews·Rowan F van GolenMichal Heger
Oct 27, 2010·International Immunopharmacology·Lydia SpurrFulvio D'Acquisto
Jun 16, 2010·Pharmacology & Therapeutics·Neil Dufton, Mauro Perretti
Oct 9, 2007·Bioorganic & Medicinal Chemistry Letters·Mike FrohnRoland W Bürli
May 4, 2007·Bioorganic & Medicinal Chemistry Letters·Olga BrunoSusanna Spisani
Feb 27, 2007·International Immunopharmacology·Yan KongYingying Le
Apr 9, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Thomas LattmannMatthias Barton
Sep 12, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Susan M YoungBruce S Edwards
Feb 21, 2008·Journal of Cellular Biochemistry·Carolina Camargo de OliveiraDorly de Freitas Buchi
Aug 19, 2010·The EMBO Journal·Anastacia Berzat, Alan Hall
Apr 25, 2012·Journal of Peptide Science : an Official Publication of the European Peptide Society·Adriano MollicaSusanna Spisani
Jun 20, 2007·Biochemical and Biophysical Research Communications·Ha Young LeeYoe-Sik Bae

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