Pleiotropic vasoprotective effects of statins: the chicken or the egg?

Drug Design, Development and Therapy
Dimitrios Kirmizis, Dimitrios Chatzidimitriou

Abstract

Statins (3-hydroxy-3-methyl glutaryl coenzyme A [HMG-CoA] reductase inhibitors) are the most commonly used lipid-lowering drugs. Their main lipid-lowering effect is achieved by an increase in the expression of low-density lipoprotein cholesterol receptors associated with inhibition of cholesterol synthesis through inhibition of HMG-CoA reductase - the first and rate-limiting step in cholesterol synthesis. However, beyond cholesterol synthesis inhibition, inhibition of the HMG-CoA reductase affects as well the synthesis of other molecules with significant roles in different, yet often intercalating, metabolic pathways. On this basis, and supported by an increasing series of advocating epidemiological and experimental data, an extended dialogue has been established over the last few years regarding the nonlipid or "pleiotropic" actions of statins.

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Citations

Oct 5, 2010·Journal of Atherosclerosis and Thrombosis·Dimitrios KirmizisDimitrios Memmos
Oct 4, 2012·Future Microbiology·Dimitrios ChatzidimitriouNikolaos Malisiovas
Dec 8, 2010·Medical Hypotheses·Antonio PiroddaClaudio Borghi
Nov 29, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Alexy RosalesLuis A Salazar
Mar 6, 2012·European Journal of Internal Medicine·Leonella PasqualiniElmo Mannarino

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Methods Mentioned

BETA
geranylation

Software Mentioned

LLA
ASCOT

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