Pleiotypic mechanisms of cellular responses to biologically active lysophospholipids

Prostaglandins & Other Lipid Mediators
Edward J Goetzl

Abstract

The activities of cell-derived lysophospholipid (LPL) growth factors on cellular proliferation and a range of proliferation-independent functions are regulated at multiple levels. This section focuses first on the capacity of the actin-severing protein gelsolin to bind lysophosphatidic acid (LPA), but not sphingosine 1-phosphate (S1P), and either sequester LPA or present it to responsive cells. Expression of members of the family of endothelial differentiation gene-encoded G protein-coupled receptors (Edg Rs) for LPLs is controlled developmentally and by cell-activating stimuli. Edg R transduction of cellular effects of LPLs involves both direct actions on target cells and induction of generation of proteins with relevant actions capable of amplifying or diminishing primary direct effects of LPLs. These general mechanisms are evident in Edg R mediation of proliferation, cytokine secretion and suppression of apoptosis. The availability of functionally-active anti-Edg R antibodies and Edg R-specific pharmacological probes, establishment of Edg R transgenes and gene knockouts, and identification of natural genetic anomalies of LPL metabolism and recognition by Edg Rs will permit elucidation of the in vivo activities of LPA and S1P...Continue Reading

References

Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·G TigyiR Miledi
Aug 1, 1995·The Journal of Membrane Biology·S Spiegel, S Milstien
Apr 1, 1997·Current Opinion in Cell Biology·W H MoolenaarG C Zondag
Dec 22, 1999·Trends in Pharmacological Sciences·K R Lynch, D S Im
May 9, 2000·The Journal of Biological Chemistry·E J GoetzlJ S Karliner

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Citations

Dec 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·M SalcedoF Wandosell
Jun 14, 2002·Trends in Cell Biology·Sarah SpiegelSheldon Milstien
Jun 19, 2002·Biochimica Et Biophysica Acta·Michael J Kluk, Timothy Hla
Jun 19, 2002·Biochimica Et Biophysica Acta·Mei Chuan HuangEdward J Goetzl
Jun 19, 2002·Biochimica Et Biophysica Acta·Tracee Scalise Panetti
Jun 19, 2002·Biochimica Et Biophysica Acta·Yuhuan XieKathryn E Meier
Dec 18, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Susumu KatsumaGozoh Tsujimoto
Jan 27, 2007·Stem Cells and Development·Rongbing ChenSteve N Georas
Aug 15, 2006·Biochemistry. Biokhimii︠a︡·O M IpatovaE M Khalilov
Sep 3, 2010·American Journal of Physiology. Cell Physiology·Robert BuckiPaul A Janmey
Jul 21, 2006·Organic & Biomolecular Chemistry·Ezio FasoliStefano Servi
Jan 18, 2003·Biochimica Et Biophysica Acta·Xiaoqin YeJerold Chun
Oct 8, 2015·British Journal of Pharmacology·Makoto KuranoYutaka Yatomi
Mar 16, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S N GeorasV Natarajan
Jul 24, 2004·Seminars in Cell & Developmental Biology·Babak Oskouian, Julie D Saba
Apr 11, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Akihiro TakateraMasafumi Matsuo
May 7, 2015·Acta Crystallographica. Section D, Biological Crystallography·Sun Hye ChoiLin Woo Kang
Jul 24, 2004·Seminars in Cell & Developmental Biology·Timothy Hla
Jul 21, 2017·Journal of Atherosclerosis and Thrombosis·Makoto Kurano, Yutaka Yatomi
Jan 21, 2004·The Journal of Biological Chemistry·Maria L AllendeRichard L Proia
Jul 2, 2003·Journal of Leukocyte Biology·Azzam A Maghazachi
Oct 22, 2002·American Journal of Physiology. Cell Physiology·De-An WangMitchell A Watsky
Jul 31, 2019·Free Radical Research·Makoto KuranoYutaka Yatomi
Oct 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hans M RosenfeldtSarah Spiegel
Jan 30, 2002·The Journal of Biological Chemistry·Lewis R VannSheldon Milstien
Jan 5, 2002·The Journal of Biological Chemistry·Hervé Le StunffSarah Spiegel
Dec 1, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H M RosenfeldtS Spiegel
Dec 19, 2002·Endocrinology·Sarah E Abbey, Lincoln R Potter
Mar 23, 2017·Journal of Atherosclerosis and Thrombosis·Chiharu TakahashiYutaka Yatomi
Oct 2, 2004·The Journal of Biological Chemistry·Maria L AllendeRichard L Proia
Dec 17, 2014·The Journal of Biological Chemistry·Makoto KuranoYutaka Yatomi
May 13, 2004·The Journal of Biological Chemistry·Mari KonoRichard L Proia
Nov 8, 2020·Rheumatology·Salem WerdyaniGuangju Zhai

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