PLEKHA5: A Key to Unlock the Blood-Brain Barrier?

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Sylvia C EiselePriscilla K Brastianos

Abstract

Brain metastases represent a devastating complication of melanoma. Our understanding of the mechanisms driving metastasis to the brain is limited. PLEKHA5 functions as a regulator of brain metastasis in melanoma, and further investigation is warranted to explore the use of PLEKHA5 as a potential therapeutic target.

References

Oct 21, 2004·Biochemical Society Transactions·M A Lemmon
Jan 26, 2013·Science·Franklin W HuangLevi A Garraway
Oct 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lawrence N Kwong, Michael A Davies
May 8, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Guo ChenMichael A Davies
Aug 29, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amanda D BucheitMichael A Davies
Oct 16, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lucia B JilaveanuHarriet M Kluger

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Citations

Nov 17, 2015·Expert Review of Molecular Diagnostics·Barbara AlberterBernhard Polzer
Jun 22, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gautham GampaWilliam F Elmquist
May 27, 2017·Current Pharmacology Reports·Gautham GampaWilliam F Elmquist
Nov 3, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Heike NiessnerFriedegund Meier

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