Pleomorphic adenoma arising in an accessory lacrimal gland of Wolfring

Ophthalmology
Ghassan Ayish AlyahyaSteffen Heegaard

Abstract

To describe a patient with pleomorphic adenoma arising in an accessory lacrimal gland of Wolfring in the lower lid and to illustrate the immunohistochemical and molecular cytogenetics. Single interventional case report. A 62-year-old man presented with a 20-year history of a painless slowly growing mass at the temporal part of the right lower eyelid. Histological, immunohistochemical, and fluorescence in situ hybridization studies of the excised tumor were performed. Histological evaluation showed many glandular elements embedded in a myxoid stroma. The tumor was situated beneath an area of a normal accessory lacrimal gland of Wolfring and in close association with normal meibomian glands. Myoepithelial tumor cells in the myxoid stroma reacted strongly with an antibody against glial fibrillary acidic protein, which did not bind to normal lacrimal gland tissue. Tumor cells with both epithelial and myoepithelial morphologies reacted positively for both pleomorphic adenoma gene-1 and high-mobility group A2 proteins. Fluorescence in situ hybridization analysis showed no evidence of clonal translocations or numerical abnormalities involving chromosome 8 or 12. Pleomorphic adenoma of the accessory lacrimal gland is an exceedingly rar...Continue Reading

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Citations

Jul 2, 2010·Nature Reviews. Drug Discovery·Anthony D KeefeAndrew Ellington
Nov 17, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Abdullah ÖzkayaAhmet Demirok
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Jun 2, 2018·Acta Ophthalmologica·Kaustubh MulaySteffen Heegaard
Jan 23, 2020·Oncology Letters·Jovanna ThielkerThomas Liehr

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