Pleomorphic adenoma of the lacrimal gland: A review with updates on malignant transformation and molecular genetics

Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society
William HarrisonThomas Cummings

Abstract

Pleomorphic adenoma (benign mixed tumor) is the most common epithelial neoplasm of the lacrimal gland. It is usually a slow growing, well-circumscribed, mass that is identical to its salivary gland counterpart. Patients generally have an excellent prognosis for vision and long-term survival after complete surgical excision. There is a tendency to reoccur, especially if there is an incomplete excision, and rarely, malignant transformation to carcinoma ex pleomorphic adenoma can occur, which has a much poorer prognosis. The molecular genetics of lacrimal gland pleomorphic adenomas have only recently been studies, but appear to display similar genetic aberration found in the salivary gland counterparts.

References

Oct 1, 1979·The American Journal of Surgical Pathology·M E LudwigR T McMahon
Jul 1, 1992·The British Journal of Ophthalmology·G E Rose, J E Wright
Oct 1, 1987·Archives of Ophthalmology·J A Shields, C L Shields
Sep 1, 1996·American Journal of Ophthalmology·E G FaktorovichC Kong
Oct 17, 2001·The British Journal of Oral & Maxillofacial Surgery·J ChandrasekharN M Whear
Feb 13, 2002·The American Journal of Pathology·Eva RöijerGöran Stenman
Oct 23, 2004·Clinical & Experimental Ophthalmology·Seema SenSupriyo Ghose
Jun 9, 2005·Reviews in Medical Virology·Renwei ChenAntti Vaheri
Aug 30, 2005·Neurologia Medico-chirurgica·Takeshi MiyazakiTatsuo Kodama
Aug 2, 2007·Ophthalmic Plastic and Reconstructive Surgery·M Reza VagefiKimberly P Cockerham
Dec 12, 2007·Archives of Ophthalmology·Zanna I Currie, Geoffrey E Rose
Aug 12, 2009·Archives of Ophthalmology·Ezekiel WeisValerie A White
Aug 27, 2013·American Journal of Ophthalmology·Pia R MendozaJeffrey F Krane
Jan 1, 2013·Journal of Surgical Case Reports·Ozcan BinatliIşın Gökçöl Erdoğan

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Citations

Feb 25, 2020·Case Reports in Oncological Medicine·Prashanth Ashok KumarAbirami Sivapiragasam
Jan 11, 2019·Acta Oto-laryngologica·Pedro ClarósAndres Clarós
Nov 12, 2020·Orbit·Huzaifa MalickRaghavan Sampath
Aug 18, 2020·American Journal of Ophthalmology·Tatyana MilmanRalph C Eagle

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Methods Mentioned

BETA
biopsy
biopsies
surgical resection

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