Pleomorphic liposarcoma: An analysis of 6 case reports and literature review

Medicine
Lianwei WangDengyang Fang

Abstract

Pleomorphic liposarcoma (PLS), is a rare subtype of liposarcoma, and is considered to be of the highest malignancy grade. We aimed to analyze the clinical features, diagnosis, treatment, and recurrence of the 6 cases of PLS. Six cases with confirmed pathological PLS presented at out hospital from January 2003 to January 2017. The postoperative pathology of 5 cases confirmed PLS, and the other was confirmed as PLS with well-differentiated liposarcoma. All 6 patients underwent complete tumor resection at the time of the first definite diagnosis, and one of them had underwent 3 cycles of chemotherapy treatment. There were 4 cases with local recurrence and surgery was repeated after the first radical excision. One case was not recurrent after 27 months post-operation, and the other was lost. The shortest recurrence time of all of these cases was 4 months, and the longest was 29 months after the first radical surgery. PLS is a rare and high-grade malignancy with high recurrence, poor prognosis, and its treatment is still highly controversial. More studies are required to determine the appropriate treatment and therapeutic strategies to improve the survival rate of patients with PLS, as the disease is associated with frequent relapse.

References

Feb 15, 2001·Pathology Oncology Research : POR·Z OroszJ Szántó
Jun 13, 2003·Skeletal Radiology·Jeffrey J PetersonMary I O'Connor
Sep 17, 2004·The American Journal of Surgical Pathology·Jason L HornickChristopher D M Fletcher
Apr 18, 2008·Diagnostic Pathology·Luka BrcićSven Seiwerth
Jul 11, 2009·Digestive Surgery·Giuseppe MalleoClaudio Bassi
Sep 4, 2009·Journal of Neuro-oncology·Michael L MumertRandy L Jensen
Jul 2, 2010·Interactive Cardiovascular and Thoracic Surgery·Ji-Gang WangYu-Jun Li
Feb 3, 2011·World Journal of Surgical Oncology·Ser Yee LeeKhee Chee Soo
Mar 23, 2011·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Erin RudzinskiMarcia Wills
Jan 1, 2014·Journal of Surgical Oncology·Karen L ShermanKarl Y Bilimoria
Feb 19, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F le GrangeB M Seddon
Jun 11, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P A CassierJ-Y Blay
Aug 8, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J T MiuraK K Turaga
Jun 29, 2016·International Journal of Surgery Case Reports·A M Morales-CodinaM Corbellas Aparicio
Sep 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P A CassierJ-Y Blay

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Citations

Feb 28, 2019·Asian Cardiovascular & Thoracic Annals·Yasir KhanSaulat Fatimi
Apr 6, 2020·Journal of Cancer Research and Clinical Oncology·Hea Gie LeeJonathan Gootee
Nov 8, 2020·Gastroenterología y hepatología·Claudia-Gabriela MoldovanuMaria-Ofelia Anton

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Methods Mentioned

BETA
biopsy
hysterectomy
surgical resection
biopsies

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