Pleomorphic xanthoastrocytoma: a comparative pathological study between conventional and anaplastic types

Histopathology
Takanori HiroseS Kannuki

Abstract

To facilitate the understanding and correct diagnosis of the anaplastic variant of pleomorphic xanthoastrocytoma (PXA). Twelve cases of PXA were divided into six conventional and six anaplastic types. Three anaplastic PXAs developed in recurrent tumours and three occurred as the primary tumour. Anaplastic PXAs were microscopically characterized by monotonous proliferation of atypical cells, increased mitotic activity, necrosis and microvascular proliferation. Characteristic features of conventional PXA are also variously included in all anaplastic PXAs. No remarkable differences were detected in the immunohistochemical profiles including the neuronal phenotype between the conventional and anaplastic types. Ki67 labelling indices of the anaplastic type were significantly higher than those of the conventional type, whereas p53 showed no difference. Immunohistochemical and fluorescence in situ hybridization analyses on epidermal growth factor receptor did not demonstrate overexpression or gene amplification. The anaplastic PXA, which occurs de novo or through recurrence, should be distinguished from glioblastoma by identifying the salient microscopic features of conventional PXA even in the anaplastic areas; and by demonstrating t...Continue Reading

References

Nov 1, 1994·Neurosurgery·D A WasdahlR A Jeffrey
Mar 1, 1994·Journal of Neurosurgery·M J HerpersE A Beuls
Jan 1, 1996·Acta Neuropathologica·W PaulusD N Louis
Jan 1, 1997·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·C BayindirD Kasaroğlu
Jul 1, 1997·The American Journal of Surgical Pathology·A PerryS Shapiro
Jan 1, 1997·Pathology, Research and Practice·I VajtaiA Aguzzi
May 29, 1998·Histopathology·N LeonardM A Farrell
Jan 15, 1999·The American Journal of Surgical Pathology·J O Zarate, R Sampaolesi
Nov 18, 2000·Archives of Pathology & Laboratory Medicine·A J EvansJ M Bilbao
Aug 29, 2001·Neurogenetics·C GianniniC D James
Mar 27, 2002·The American Journal of Surgical Pathology·Caterina GianniniScott R VandenBerg
Sep 18, 2002·Neurosurgery·Kazunori AritaTakanori Hirose
Dec 18, 2002·Journal of Neuropathology and Experimental Neurology·Kerstin KaulichGuido Reifenberger
Mar 8, 2003·Acta Neuropathologica·G ReifenbergerI Blümcke
Apr 26, 2003·Arquivos de neuro-psiquiatria·Oswaldo Ignácio de TellaPaulo Henrique Aguiar
May 7, 2003·Asian Journal of Surgery·Noor Azam NasuhaMohd Nizam Isa
Dec 12, 2003·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Alphonse LubansuBenoit Pirotte
Jan 21, 2004·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Tze-Ching TanFung-Ching Cheung
Sep 30, 2004·Acta neurochirurgica·R Gil-GouveiaJ Pimentel
Feb 17, 2005·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Todd W KelleyRichard A Prayson
May 25, 2005·Acta neurochirurgica·T NakajimaT Tominaga
Dec 27, 2006·Journal of the Neurological Sciences·Elisabetta MartonPierluigi Longatti
May 1, 2007·Journal of Chemical Neuroanatomy·G F JirikowskiJ D Caldwell

❮ Previous
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Citations

Jul 6, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nicola MontanoMario Meglio
Jan 7, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yong-Juan FuHitoshi Takahashi
Feb 2, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Takashi OhtaMasahiko Sugitani
Feb 5, 2013·Neurosurgical Focus·Nicholas F Marko, Robert J Weil
Mar 22, 2013·British Journal of Neurosurgery·Pasquale GalloGiampietro Pinna
Mar 14, 2018·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Takuya FurutaYasuo Sugita
Mar 6, 2013·Brain Tumor Pathology·Kosuke KatayamaAkira Kurose
Aug 3, 2013·Journal of Korean Neurosurgical Society·Sungryong LimChang Jin Kim
Oct 17, 2014·Brain Pathology·Cristiane M IdaCaterina Giannini
Apr 5, 2013·The American Journal of Surgical Pathology·Bette Kay Kleinschmidt-DeMastersNicholas K Foreman
Jul 19, 2019·Journal of Current Ophthalmology·Roshanak Aliakbar NavahiMohammadreza Ahangarani
Oct 26, 2012·Journal of Neuro-oncology·Yao SchmidtDenise Damek
Jun 16, 2018·AJNR. American Journal of Neuroradiology·D SheZ Zhang
Apr 30, 2020·World Neurosurgery·Sang Ho KimChae-Yong Kim
May 11, 2021·Journal of Neuro-oncology·Adrian RodriguesMelanie Hayden-Gephart

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