PMID: 8597455Dec 29, 1995Paper

Pleotropic effects of dietary DHEA

Annals of the New York Academy of Sciences
L MilewichM Bennett

Abstract

We present data pertaining to some of the in vivo effects associated with dietary DHEA administration to mice and rats. Dietary DHEA leads to: (1) decrease in body weight gain; (2) relative increases in liver weight; (3) liver color change; (4) induction of hepatic peroxisomal enzymes; (5) proliferation of hepatic peroxisomes with increased cross-sectional area; (6) decreased hepatic mitochondrial cross-sectional area; (7) elevated levels of hepatic cytosolic malic enzyme; (8) slight decreases, significant decreases, or significant increases in serum triglyceride levels, depending on mouse strain; (9) increases in total serum cholesterol levels; (10) significant decreases in the hepatic rates of fatty acid synthesis; (11) significant increases in the hepatic rates of cholesterol synthesis; (12) decreases in both protein content and specific activity of hepatic mitochondrial carbamoyl phosphate synthetase-I without concomitant changes in serum urea nitrogen; (13) induction of glutathione S-transferase activity in liver; (14) decrease in hepatic endogenous protein phosphorylation; (15) increase in hepatic AMPase and GTPase activities; (16) formation of 5-androstene-3 beta,17 beta-diol as a major metabolite of DHEA by subcellular ...Continue Reading

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Citations

Apr 17, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M F KnapenE A Steegers
Nov 7, 1998·Molecular and Cellular Endocrinology·K P NephewS A Khan
Jul 1, 1997·Baillière's Clinical Endocrinology and Metabolism·F Svec
Sep 9, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Anne R CappolaLinda P Fried
Apr 19, 2018·EMBO Molecular Medicine·T Katherine TamaiTakashi Yoshimura
May 13, 2003·Microscopy Research and Technique·Marianne DepreterFrank Roels

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