Plethysmographic arterial waveform strain discrimination by Fisher's method

Ultrasound in Medicine & Biology
John C KucewiczKirk W Beach

Abstract

Plethysmography has been used for over 50 years to measure gross change in tissue blood volume. Over the cardiac cycle, perfused tissue initially expands as the blood flow into the arterioles exceeds the flow through the capillary bed. Later in the cardiac cycle, the accumulated blood drains into the venous vasculature, allowing the tissue to return to its presystolic blood volume. Specific features in the plethysmographic waveform can be used to identify normal and abnormal perfusion. We are developing a Doppler strain-imaging technique to measure the local pulsatile expansion and relaxation of tissue analogous to the gross measurement of tissue volume change with conventional plethysmography. A phantom has been built to generate plethysmographic-style strains with amplitudes of less than 0.1% in a tissue-mimicking material. With Fisher's discriminant analysis, it is shown that normal and abnormal plethysmographic-style strains can be differentiated with high sensitivities using the Fourier components of the strain waveforms normalized to compensate for the variance in the strain amplitude estimate.

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Citations

Mar 10, 2007·Ultrasound in Medicine & Biology·John C KucewiczKirk W Beach
Sep 14, 2007·Veterinary Anaesthesia and Analgesia·Christine BaumgartnerWolf Erhardt
Mar 14, 2008·Ultrasound in Medicine & Biology·John C KucewiczKirk W Beach
Jun 7, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas DesmidtVincent Camus
Aug 8, 2020·Brain Imaging and Behavior·Marta Andrea SiragusaThomas Desmidt

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