Plethysmographic estimation of thoracic gas volume in apneic mice

Journal of Applied Physiology
Tibor Z JanosiZoltán Hantos

Abstract

Electrical stimulation of intercostal muscles was employed to measure thoracic gas volume (TGV) during airway occlusion in the absence of respiratory effort at different levels of lung inflation. In 15 tracheostomized and mechanically ventilated CBA/Ca mice, the value of TGV obtained from the spontaneous breathing effort available in the early phase of the experiments (TGVsp) was compared with those resulting from muscle stimulation (TGVst) at transrespiratory pressures of 0, 10, and 20 cmH2O. A very strong correlation (r2= 0.97) was found, although with a systematically (approximately 16%) higher estimation of TGVst relative to TGVsp, attributable to the different durations of the stimulated (approximately 50 ms) and spontaneous (approximately 200 ms) contractions. Measurements of TGVst before and after injections of 0.2, 0.4, and 0.6 ml of nitrogen into the lungs in six mice resulted in good agreement between the change in TGVst and the injected volume (r2= 0.98). In four mice, TGVsp and TGVst were compared at end expiration with air or a helium-oxygen mixture to confirm the validity of isothermal compression in the alveolar gas. The TGVst values measured at zero transrespiratory pressure in all CBA/Ca mice [0.29 +/- 0.05 (SD...Continue Reading

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Citations

Aug 7, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·M V SzabariB Suki
Oct 11, 2008·Journal of Applied Physiology·Z HantosB Suki
Nov 11, 2008·American Journal of Respiratory and Critical Care Medicine·Michael J BrennickRichard J Schwab
Feb 8, 2011·American Journal of Respiratory and Critical Care Medicine·Graeme R ZoskyPrue H Hart
Dec 15, 2012·Respiratory Research·Ferenc PetakWalid Habre
Feb 20, 2013·BMC Pharmacology & Toxicology·Kathryn A RamseyGraeme R Zosky
Dec 12, 2012·Environmental Health Perspectives·Kathryn A RamseyGraeme R Zosky
Aug 24, 2013·Environmental Health Perspectives·Kathryn A RamseyGraeme R Zosky
Jun 3, 2008·Respiratory Physiology & Neurobiology·Vincenzo CannizzaroPeter D Sly
Apr 29, 2008·Respiratory Physiology & Neurobiology·Alexander N LarcombePeter D Sly
Dec 12, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G R ZoskyD J Turner
May 28, 2014·Inhalation Toxicology·Alexander N LarcombeBenjamin J Mullins
Apr 22, 2015·Respiratory Physiology & Neurobiology·M V SzabariZ Hantos
Mar 1, 2016·The Journal of Pathology·Teruhiko SatoMarc G Achen
Jul 12, 2018·Clinical and Experimental Pharmacology & Physiology·Iliona MalaspinasWalid Habre
Dec 23, 2017·Clinical Science·Kimberley C W WangPeter B Noble
May 15, 2007·Journal of Applied Physiology·Elizabeth M BozanichPeter D Sly
Feb 9, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Walid HabreFerenc Peták
May 21, 2011·Journal of Applied Physiology·Sam BayatWalid Habre
Nov 28, 2019·American Journal of Respiratory Cell and Molecular Biology·Alexander N LarcombePeter B Noble
Jun 17, 2008·Journal of Applied Physiology·Graeme R ZoskyZoltán Hantos
Oct 19, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Vincenzo CannizzaroGraeme R Zosky
Apr 11, 2020·Respiratory Research·Roberta SüdyFerenc Peták
Apr 1, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alexander N LarcombePeter J Franklin

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