Pleural effusion in lung cancer: more questions than answers

Respiration; International Review of Thoracic Diseases
Marios E Froudarakis

Abstract

Lung cancer remains the most common fatal malignancy, despite more aggressive therapies. Few patients will survive 5 years, as up to 80% of the patients will present with advanced-stage disease at diagnosis. Chemotherapy offers little benefit in terms of median survival and disease-free survival in patients with advanced-stage non-small-cell lung carcinoma (NSCLC). In the last decade, the development of new targeted therapies based on the better understanding of different paths of carcinogenesis has given new hope to both physicians and patients. Metastatic pleural effusion from lung cancer has a particularly poor prognosis, and in NSCLC it is actually reclassified as stage IV disease. A possible explanation of this observation is differences in the genomics between primary tumors and metastasis, leading to possible different therapeutic approaches with novel molecular therapies in this patient population. The current review aims to summarize the actual situation of research in pleural disease due to lung carcinoma in relation to novel targeted therapies tested in this patient population.

References

Aug 1, 1992·American Journal of Respiratory Cell and Molecular Biology·G Murphy, A J Docherty
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S IshiiI Pastan
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A J ClarkI Pastan
Jun 1, 1994·Thorax·C M O'Connor, M X FitzGerald
Jan 1, 1997·The European Respiratory Journal·G Miserocchi
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·O EickelbergA P Perruchoud
Jul 1, 1998·Clinics in Chest Medicine·S A Sahn
Sep 24, 1999·Chest·D ChengR W Light
Jun 11, 2002·Current Opinion in Pulmonary Medicine·Carolyn S Grove, Y C Gary Lee
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giorgio V ScagliottiFred R Hirsch
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giuseppe Giaccone
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joanne R Brown, Raymond N DuBois
Nov 16, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jean-Yves DouillardLesley Seymour
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shiu-Feng HuangShih-Feng Tsai
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Donald BissettFrances A Shepherd
Apr 13, 2005·Respiration; International Review of Thoracic Diseases·Kwang Joo ParkKyi Beum Lee
Jan 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroaki AsanoNobuyoshi Shimizu
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gregory J RielyVincent A Miller
Apr 20, 2006·International Journal of Clinical Oncology·Seiji YanoSaburo Sone
Jun 23, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·O PichelmayerM Raderer
Aug 11, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Elisabetta PaceMark Gjomarkaj
Aug 22, 2006·International Journal of Cancer. Journal International Du Cancer·Junichi SohHiroshi Date
Dec 5, 2006·Japanese Journal of Clinical Oncology·Reury-Perng PerngChao-Hua Chiu
Dec 13, 2006·Journal of Medical Genetics·Xiaozhu Zhang, Alex Chang
Jul 13, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Frances A Shepherd, Rafael Rosell
Jul 17, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·David A Keays
Jul 20, 2007·Current Treatment Options in Oncology·Elwyn Cabebe, Heather Wakelee
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN Participating Institutions
Dec 7, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xiaozhu ZhangAlex Yuang-chi Chang
Dec 20, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Frances A ShepherdUNKNOWN International Association for the Study of Lung Cancer International Staging Committee and Participating Institutions
Jan 11, 2008·Respiration; International Review of Thoracic Diseases·Marios E Froudarakis
Mar 12, 2008·Respiration; International Review of Thoracic Diseases·Michael A Jantz, Veena B Antony
Apr 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Anuj AgarwalaNasser Hanna

❮ Previous
Next ❯

Citations

Aug 24, 2013·PloS One·Antonia MaraziotiGeorgios T Stathopoulos
Sep 28, 2013·BioMed Research International·Cecilia MennaErino A Rendina
Apr 5, 2013·Expert Opinion on Medical Diagnostics·Francisco Rodriguez-Panadero, Beatriz Romero-Romero
Apr 14, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Liwen ChenShihe Guan
Dec 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhi-Feng MiaoHui-Mian Xu
Jul 6, 2014·Cytokine·Vasiliki I PeppaChrissi Hatzoglou
May 22, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Daye ChengYunhui Li
Jun 7, 2015·Respiratory Medicine·Georgia KarpathiouMarios E Froudarakis
Dec 3, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Giorgio TregliaLuca Giovanella
Apr 19, 2015·BMC Pulmonary Medicine·Mauro Musa ZamboniGilberto Perez Cardoso
Jul 28, 2016·International Journal of Cancer. Journal International Du Cancer·Lifeng LiYi Zhang
Sep 25, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jiyoul YangHye Sook Han
Feb 10, 2019·The Clinical Respiratory Journal·Claire TissotMarios E Froudarakis
May 12, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jonathan Caleb QuekDevanand Anantham
Aug 1, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Alexandra Dipper, Nick Maskell
Dec 10, 2020·EMBO Molecular Medicine·Julie KoJulien Sage
Nov 17, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yusuke FujibayashiWataru Nishio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Related Papers

Respirology : Official Journal of the Asian Pacific Society of Respirology
Ioannis Kalomenidis
Thoracic Surgery Clinics
Rajesh Thomas, Y C Gary Lee
Seminars in Respiratory and Critical Care Medicine
Peter Doelken
JAMA : the Journal of the American Medical Association
Nick A Maskell
© 2021 Meta ULC. All rights reserved