Pleural fluid interleukin-8 and C-reactive protein for discriminating complicated non-purulent from uncomplicated parapneumonic effusions

Respirology : Official Journal of the Asian Pacific Society of Respirology
José M PorcelManuel Vives

Abstract

This study was designed to test the hypothesis that measurement of IL-8 and CRP in pleural fluid could improve the identification of patients with non-purulent parapneumonic effusions that ultimately require chest tube drainage. We assessed IL-8, CRP and three classical parameters (pH, glucose and LDH) in the pleural fluid of 100 patients with parapneumonic effusions. Forty-nine of these patients had non-purulent complicated effusions (complicated parapneumonic pleural effusion, CPPE), and 51 had uncomplicated parapneumonic pleural effusions (UPPE). Receiver-operating characteristic curves were used to assess the sensitivity and specificity of pleural fluid biochemical parameters for differentiating among the two patient groups. IL-8 production was determined using a commercially available ELISA kit, and CRP was measured by immunoassay. At a cutoff value of 1000 pg/mL, IL-8 differentiated CPPE from UPPE with a sensitivity of 84% and a specificity of 82%. Likewise, CRP levels were higher in CPPE than in UPPE, and showed 72% sensitivity and 71% specificity at a cutoff value of 80 mg/L. We found that all five pleural fluid tests showed similar diagnostic accuracies when evaluated by receiver-operating characteristic analysis. Howe...Continue Reading

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Citations

Mar 12, 2009·Current Opinion in Pulmonary Medicine·Mateo Cabre
Mar 13, 2010·Current Opinion in Pulmonary Medicine·José M Porcel
Feb 5, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Richard Ruffin, Philip G Bardin
Apr 9, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Martin R J Kolb, Ian Yang
Oct 15, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Vasileios SkourasKonstantinos I Gourgoulianis
Mar 27, 2012·Pulmonary Medicine·T HassanN G McElvaney
Feb 16, 2013·Clinics in Chest Medicine·José M Porcel
Feb 16, 2013·Clinics in Chest Medicine·Rahul Bhatnagar, Nick A Maskell
Jun 26, 2012·European Journal of Internal Medicine·José M PorcelMiquel Falguera
May 18, 2010·American Journal of Clinical Pathology·M Esther San JoséAngel Segade
Mar 31, 2015·Archivos de bronconeumología·Lucía FerreiroLuis Valdés
Dec 3, 2010·European Journal of Clinical Investigation·Irene TsilioniTheodoros S Kiropoulos
May 29, 2015·Current Opinion in Pulmonary Medicine·José M Porcel
Apr 16, 2010·Respiratory Medicine·Emmet E McGrathPaul B Anderson
May 22, 2018·Expert Review of Respiratory Medicine·Lucía FerreiroLuis Valdés
Sep 23, 2014·American Journal of Clinical Pathology·M Esther San JoséLuis Valdés
Aug 16, 2018·Prilozi·Sanja Petrusevska MarinkovicAnkica Anastasovska
Feb 26, 2019·Revue des maladies respiratoires·M NeuvilleL Bouadma

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