Pleural mesothelioma with cutaneous extension to chest wall scars

Journal of Cutaneous Pathology
Sherry ShiehRichard T Cheney

Abstract

Cutaneous mesothelioma is rare but may occur following local surgical procedures for visceral mesothelioma or as a metastasis. A patient with pleural mesothelioma, who developed papules within chest wall scars, 14 and 15 months after pleural biopsy and thoracentesis, respectively, is reported. Histopathology showed an epithelioid tumor forming tubulopapillary and glandular structures. The diagnosis of mesothelioma was confirmed with immunohistochemistry. Tumor cells stained characteristically for low-molecular-weight cytokeratins 5/6, calretinin, and vimentin and were negative for mucicarmine, carcinoembryonic antigen, thyroid transcription factor 1, prostate-specific antigen, gross cystic disease fluid protein, S-100, factor VIII, and CD31. Histologically, mesothelioma may resemble a primary adnexal neoplasm, metastatic adenocarcinoma, or angiosarcoma. Immunohistochemistry can clarify the diagnosis. Clinicians should be aware of the varied presentations of mesothelioma, as cutaneous presentations are becoming increasingly common.

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Citations

Aug 2, 2007·The American Journal of Dermatopathology·Trevor W Beer, Peter J Heenan
May 24, 2012·The American Journal of Dermatopathology·Inmaculada AlcarazLuis Requena
Jun 12, 2009·Journal of Cutaneous Pathology·Cynthia Abban, Michael Viglione
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Jan 31, 2006·Journal of the American Academy of Dermatology·Antonio MaioranaGiulio Rossi
Oct 24, 2017·The American Journal of Dermatopathology·Nikolai KlebanovHensin Tsao
Aug 12, 2017·Journal of Cutaneous Pathology·Rachel Elizabeth WardMatthew Kuhar
Jan 4, 2019·Archives of Pathology & Laboratory Medicine·Gabriel Habermehl, Jennifer Ko
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Dec 2, 2020·Journal of Cutaneous Pathology·Katrina CollinsPhyu P Aung
Aug 31, 2019·Dermatologic Clinics·Evan Alexander ChoateScott Worswick

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