Pleurodesis induced by talc or silver nitrate: evaluation of collagen and elastic fibers in pleural remodeling.

Lung
L AntonangeloE Marchi

Abstract

This study evaluated the extracellular matrix (collagen and elastic fibers) in pleurodesis induced by intrapleural talc (TL) or silver nitrate (SN). Study subjects were 420 rabbits divided into two groups and sacrificed from 15 min to 12 months after the injection of the sclerosing agents at intervals previously defined. Pleural adhesions and fibrosis were graded (0-4), and the collagen and elastin were quantified. The maximum score of the pleural adhesions was observed two months after TL (2.80 +/- 0.99) and 15 days after SN (3.75 +/- 0.25). More intense pleural adhesions were observed in the SN group from day 5 (p < 0.05). Pleural thickness and pleural fibrosis were, in general, significantly higher after SN (p < 0.05). Increased deposition of collagen and elastin was observed in both groups but was more evident in the SN group. In the TL group, a linear correlation was observed between pleural adhesions and fibrosis (r = 0.775), between pleural adhesions and collagen (r = 0.779), and between fibrosis and collagen (r = 0.709). In the SN group, these correlations were acceptable (r = 0.605, 0.665, and 0.663). The elastin presented a correlation of 0.707 (p < 0.001) in the TL group and of 0.564 (p < 0.001) in the SN group. In c...Continue Reading

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Citations

Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Saraschandra NaragintiVaibhav Vilas Andhalkar
Nov 1, 2006·ChemMedChem·Jun TianPaul K H Tam
May 28, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Lisete R TeixeiraEvaldo Marchi
Jan 31, 2012·Respiration; International Review of Thoracic Diseases·Francisco Rodriguez-Panadero, Ana Montes-Worboys

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