PMID: 25762646Mar 13, 2015Paper

Plexin-B2 promotes invasive growth of malignant glioma

Oncotarget
Audrey P LeRoland H Friedel

Abstract

Invasive growth is a major determinant of the high lethality of malignant gliomas. Plexin-B2, an axon guidance receptor important for mediating neural progenitor cell migration during development, is upregulated in gliomas, but its function therein remains poorly understood. Combining bioinformatic analyses, immunoblotting and immunohistochemistry of patient samples, we demonstrate that Plexin-B2 is consistently upregulated in all types of human gliomas and that its expression levels correlate with glioma grade and poor survival. Activation of Plexin-B2 by Sema4C ligand in glioblastoma cells induced actin-based cytoskeletal dynamics and invasive migration in vitro. This proinvasive effect was associated with activation of the cell motility mediators RhoA and Rac1. Furthermore, costimulation of Plexin-B2 and the receptor tyrosine kinase Met led to synergistic Met phosphorylation. In intracranial glioblastoma transplants, Plexin-B2 knockdown hindered invasive growth and perivascular spreading, and resulted in decreased tumor vascularity. Our results demonstrate that Plexin-B2 promotes glioma invasion and vascularization, and they identify Plexin-B2 as a potential novel prognostic marker for glioma malignancy. Targeting the Plexin...Continue Reading

References

Aug 29, 2002·Nature Cell Biology·Silvia GiordanoPaolo M Comoglio
Jun 24, 2004·The Journal of Cell Biology·Jakub M SwierczStefan Offermanns
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Oct 11, 2005·Neuro-oncology·Roger Abounader, John Laterra
Dec 5, 2006·Methods in Enzymology·Rodney L Rietze, Brent A Reynolds
Apr 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roland H FriedelAlain Chédotal
Jun 8, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suhua DengRohini Kuner
Nov 1, 2007·Journal of the National Cancer Institute·Dominique B HoelzingerMichael E Berens
Apr 1, 2008·Trends in Biochemical Sciences·Yeping ZhouR Jeroen Pasterkamp
Jun 27, 2008·Nature Reviews. Cancer·Gera Neufeld, Ofra Kessler
Dec 3, 2010·Molecular and Cellular Neurosciences·Viola MaierRoland H Friedel
Mar 2, 2012·The Journal of Clinical Investigation·Thomas WorzfeldStefan Offermanns
Apr 18, 2012·Genes & Development·Gavin P DunnWilliam C Hahn
Nov 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bhaskar SahaAlain Chédotal
Oct 15, 2013·Cell·Cameron W BrennanUNKNOWN TCGA Research Network
Jun 21, 2014·Nature Reviews. Neuroscience·Vishnu Anand CuddapahHarald Sontheimer
Aug 2, 2014·Nature Reviews. Drug Discovery·Thomas Worzfeld, Stefan Offermanns

❮ Previous
Next ❯

Citations

May 6, 2019·International Journal of Molecular Sciences·Cristiana AngelucciGigliola Sica
Aug 24, 2019·International Journal of Cancer. Journal International Du Cancer·Ilya V UlasovMaciej S Lesniak
Sep 4, 2017·Journal of Molecular Neuroscience : MN·Elizabeth M EllisonMark A Lovell
Jun 14, 2016·Cell Adhesion & Migration·Sreeharsha Gurrapu, Luca Tamagnone
Nov 19, 2015·Developmental Neurobiology·Nicolas DaviaudHongyan Zou
Oct 5, 2019·Oncogene·Branden A SmeesterBranden S Moriarity
Jan 31, 2021·Communications Biology·Yong HuangRoland H Friedel
Jul 8, 2018·Molecular and Cellular Neurosciences·Jacqueline E McDermottSuzanne Paradis
Nov 3, 2016·Journal of Cell Science·Brad McCollAnne J Ridley
May 21, 2021·Neuro-oncology Advances·Anju KarkiCharles Keller
Aug 3, 2021·Experimental Cell Research·Pritam Kumar RoyMahitosh Mandal
Oct 16, 2021·Nature Communications·Chrystian Junqueira AlvesRoland H Friedel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Related Papers

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
Kenta MasudaShinobu Inagaki
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Roland H FriedelAlain Chédotal
The Journal of Immunology : Official Journal of the American Association of Immunologists
Claudia MedaEnrico Giraudo
© 2021 Meta ULC. All rights reserved