Jun 26, 2004

Plexin-B3 is a functional receptor for semaphorin 5A

EMBO Reports
Stefania ArtigianiLuca Tamagnone

Abstract

Semaphorins are a large family of molecular cues implicated in neural development and in a variety of functions outside the nervous system. Semaphorin 5A (Sema5A) is a transmembrane semaphorin, containing seven thrombospondin type-1 repeats, which was recently found to control axon guidance. Here we show that plexin-B3 is a high-affinity receptor specific for Sema5A. We further demonstrate that plexin-B3 activation by Sema5A mediates functional responses in plexin-B3-expressing cells (either fibroblasts, epithelial and primary endothelial cells). In addition, Sema5A can trigger the intracellular signalling of the hepatocyte growth factor/scatter factor receptor, Met, associated in a complex with plexin-B3. We thus conclude that Sema5A is able to elicit multiple functional responses through its receptor plexin-B3.

  • References19
  • Citations77

Mentioned in this Paper

Specimen Type - Fibroblasts
Cell Motility
Hormone Receptors, Cell Surface
Protoplasm
Entire Nervous System
Hepatocyte Growth Factor
COS-7 Cells
Integral to Membrane
Plasma Protein Binding Capacity
MET protein, human

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