PMID: 11604131DOI: 10.1016/s0896-6273(01)00459-7Oct 18, 2001Paper
Plexin signaling via off-track and rho family GTPases
Neuron
K L Whitford, A Ghosh
Abstract
Two papers in this issue of Neuron examine new aspects of Semaphorin signaling via Plexin receptors. Winberg et al. present evidence that the transmembrane protein Off-track (OTK) interacts biochemically and genetically with Plexin A and is important for Sema 1a repulsive signaling. Hu et al. examine the coupling of Plexin B to Rac and RhoA and propose that Plexin B signaling involves inhibition of Rac function by direct sequestration and simultaneous activation of RhoA.
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Citations
Apr 12, 2008·Purinergic Signalling·Rodrigo A Cunha
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