Abstract
Axonal growth from both intact and severed fibers is limited after adult mammalian CNS injury. Myelin proteins contribute to inhibition of axonal growth. Semaphorin6A protein inhibits the extension of developing axons and is highly expressed in adult oligodendrocytes. This expression pattern suggests that a developmental axon guidance cue contributes to the restriction of adult CNS growth. Here, we assessed the role of a Sema6A receptor, PlexinA2, in recovery from adult trauma. Adult sensory neuron inhibition by Sema6A requires PlexinA2, with complete protection in PlexinA2-/- cultures. Mice lacking another myelin inhibitor receptor, NgR1, are known to exhibit greater axonal sprouting and functional recovery after lesions of the corticospinal tract at the medullary pyramid, so we investigated PlexinA2 in this lesion. Without injury, the corticofugal projection into the cervical spinal cord is normal in adult PlexinA2 null mice. After unilateral pyramidotomy, unlesioned PlexinA2-/- corticospinal fibers sprout across the midline to innervate the contralateral gray matter of the spinal cord to a significantly greater extent than do fibers in wild type mice. Sprouted fibers display frequent synaptophysin-positive synaptic puncta. T...Continue Reading
References
Nov 15, 1996·Science·M Tessier-Lavigne, C S Goodman
Jan 6, 1999·Cell·M L WinbergC S Goodman
Apr 8, 1999·Molecular and Cellular Neurosciences·R J PasterkampJ Verhaagen
Oct 16, 1999·Cell·T TakahashiS M Strittmatter
Mar 10, 2001·Neuron·T Takahashi, S M Strittmatter
Mar 10, 2001·Nature·P A LeightonM Tessier-Lavigne
May 16, 2002·Experimental Neurology·F De WinterJ Verhaagen
May 20, 2003·Journal of Neurochemistry·Rick I CohenLynn D Hudson
Apr 20, 2004·Neuroreport·T LindholmM Risling
May 28, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeffrey L GoldbergBen A Barres
Oct 27, 2004·Neuron·Ji-Eun KimStephen M Strittmatter
Jan 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Binhai ZhengMarc Tessier-Lavigne
Jan 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karthik VenkateshRoman J Giger
Apr 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fumikazu SutoHajime Fujisawa
Oct 6, 2005·Nature Neuroscience·Géraldine KerjanAlain Chédotal
Jul 22, 2006·Nature Reviews. Neuroscience·Noam Y Harel, Stephen M Strittmatter
Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Betty P LiuStephen M Strittmatter
Nov 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William B J Cafferty, Stephen M Strittmatter
Feb 14, 2007·Neuron·Fumikazu SutoHajime Fujisawa
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William B J CaffertyStephen M Strittmatter
Jun 2, 2007·Annual Review of Cell and Developmental Biology·Tracy S TranRajnish Bharadwaj
Nov 13, 2007·Molecular and Cellular Neurosciences·Erik MireGeneviève Rougon
Nov 8, 2008·Science·Jasvinder K AtwalMarc Tessier-Lavigne
Dec 10, 2008·Neural Development·Annette E RünkerKevin J Mitchell
Oct 17, 2009·Science·Yingjie ShenJohn G Flanagan
May 21, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William B J CaffertyStephen M Strittmatter
Jul 8, 2010·The EMBO Journal·Liat Haklai-TopperAvraham Yaron
Citations
Feb 14, 2014·PloS One·Anne JacobiFlorence M Bareyre
Nov 10, 2013·Journal of Molecular Neuroscience : MN·Jianqiang Wen, Meili Liu
Oct 26, 2013·Molecular Neurobiology·Oscar Seira, José Antonio Del Río
Oct 11, 2014·Gene·Aisling M O'MalleyDenis S Barry
Jun 25, 2014·Neuroscience Bulletin·Dingding ShenXiaosong Gu
Nov 24, 2012·Neurobiology of Disease·Pawel NamsolleckU Muscha Steckelings
Sep 17, 2013·Glia·Miranda WithefordA Jane Roskams
Oct 10, 2013·The European Journal of Neuroscience·Anissa KempfMartin E Schwab
Apr 1, 2015·Progress in Biophysics and Molecular Biology·Heath G PascoeXuewu Zhang
Apr 16, 2013·The Biochemical Journal·Juan Felipe Diaz Quiroz, Karen Echeverri
Dec 6, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Yong-Hwee Eddie LohHongyan Zou
Jan 23, 2017·Neuroscience Letters·Kerstin HåkanssonColm M P O'Tuathaigh
Jul 12, 2018·PloS One·Harrison P FisherHadley W Horch
Aug 2, 2014·Nature Reviews. Drug Discovery·Thomas Worzfeld, Stefan Offermanns
Mar 15, 2015·The EMBO Journal·Anne JacobiFlorence M Bareyre
Sep 6, 2014·Biofabrication·J Lowry CurleyMichael J Moore
May 7, 2020·Brain : a Journal of Neurology·Xingxing WangStephen M Strittmatter
Jun 22, 2020·Cerebral Cortex·Masaki UenoYutaka Yoshida
Aug 5, 2020·Development·Xiaoyu WangYuan Wang
Mar 27, 2020·Frontiers in Neuroscience·Michael J RigbyLuigi Puglielli
Nov 4, 2020·Stroke; a Journal of Cerebral Circulation·Yi ZhangZheng Gang Zhang
Aug 4, 2021·Molecular Neurobiology·Syed Faraz KazimMeic H Schmidt
Sep 3, 2021·Experimental Neurology·Sisi LiJianguang Xu