PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development

Developmental Cell
Aaron D GitlerJonathan A Epstein

Abstract

The identification of new signaling pathways critical for cardiac morphogenesis will contribute to our understanding of congenital heart disease (CHD), which remains a leading cause of mortality in newborn children worldwide. Signals mediated by semaphorin ligands and plexin receptors contribute to the intricate patterning of axons in the central nervous system. Here, we describe a related signaling pathway involving secreted class 3 semaphorins, neuropilins, and a plexin receptor, PlexinD1, expressed by endothelial cells. Interruption of this pathway in mice results in CHD and vascular patterning defects. The type of CHD caused by inactivation of PlexinD1 has previously been attributed to abnormalities of neural crest. Here, we show that this form of CHD can be caused by cell-autonomous endothelial defects. Thus, molecular programs that mediate axon guidance in the central nervous system also function in endothelial cells to orchestrate critical aspects of cardiac morphogenesis.

References

Jul 1, 1995·The Journal of Clinical Investigation·Y KuriharaY Yazaki
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·K T HallG J Freeman
Aug 22, 1997·Cell·A L KolodkinD D Ginty
Apr 29, 1998·Annual Review of Physiology·T L CreazzoM L Kirby
Jul 3, 1998·The Journal of Clinical Investigation·H YanagisawaM Yanagisawa
Apr 10, 1999·Nature Neuroscience·T TakahashiS M Strittmatter
Oct 16, 1999·Cell·T TakahashiS M Strittmatter
Feb 19, 2000·Current Opinion in Neurobiology·J A Raper
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Seiji TakashimaMasatsugu Hori
Aug 24, 2002·Scandinavian Journal of Immunology·S HolmesC Lewis
Oct 11, 2002·Nature·Atsushi KumanogohHitoshi Kikutani
Nov 2, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bert van der ZwaagHans Van Bokhoven
Nov 5, 2002·Developmental Biology·Lazaros KochilasJonathan A Epstein
Jan 23, 2003·Nature Medicine·Ingeborg StalmansPeter Carmeliet
Jul 16, 2003·Cold Spring Harbor Symposia on Quantitative Biology·A D GitlerJ A Epstein
Oct 17, 2003·The Journal of Clinical Investigation·Alexandra AbramssonChrister Betsholtz
Jul 9, 2004·Developmental Cell·Jesús Torres-VázquezBrant M Weinstein

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Citations

Jan 9, 2009·Angiogenesis·Domenico RibattiEnrico Crivellato
Mar 7, 2009·Angiogenesis·Guido SeriniFederico Bussolino
Sep 5, 2007·Cancer Metastasis Reviews·Diane R Bielenberg, Michael Klagsbrun
Dec 17, 2005·Cancer Letters·Noga Guttmann-RavivGera Neufeld
Dec 19, 2007·Nature Immunology·Kazuhiro SuzukiHitoshi Kikutani
May 21, 2013·Nature Medicine·Karl DegenhardtJonathan A Epstein
Apr 10, 2007·Nature Medicine·Masaki IedaKeiichi Fukuda
Dec 7, 2007·Nature Neuroscience·Gang ChenXiao-Bing Yuan
Jun 27, 2008·Nature Reviews. Cancer·Gera Neufeld, Ofra Kessler
Nov 30, 2005·Nature Reviews. Molecular Cell Biology·Robert P KrugerKun-Liang Guan
May 25, 2007·Nature Reviews. Molecular Cell Biology·Ralf H Adams, Kari Alitalo
Aug 24, 2011·Nature Reviews. Molecular Cell Biology·Shane P Herbert, Didier Y R Stainier
Jul 15, 2005·Cell Death and Differentiation·A ChédotalC Moreau-Fauvarque
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Arun PadmanabhanJonathan A Epstein
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kazuki KodoHiroyuki Yamagishi
May 26, 2011·The Journal of Biological Chemistry·Hui WangHee-Won Park
May 24, 2007·Tissue Engineering·Takuya MatsumotoDavid J Mooney
Jan 17, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sei Kuriyama, Roberto Mayor
May 11, 2010·Cold Spring Harbor Perspectives in Biology·Ralf H Adams, Anne Eichmann
May 4, 2012·Cold Spring Harbor Perspectives in Medicine·Aniket V GoreBrant M Weinstein
Oct 7, 2009·Molecular and Cellular Biology·Jakub M SwierczStefan Offermanns
Apr 14, 2010·Molecular and Cellular Biology·Atsuko SakuraiJ Silvio Gutkind
Apr 7, 2010·Annual Review of Neuroscience·Stephen J Tam, Ryan J Watts
Jun 2, 2007·Annual Review of Cell and Developmental Biology·Tracy S TranRajnish Bharadwaj
Mar 2, 2010·Circulation. Cardiovascular Imaging·Karl DegenhardtJonathan A Epstein
May 21, 2010·Circulation. Cardiovascular Imaging·Margaret L Kirby, David J Sahn
Apr 18, 2013·American Journal of Respiratory Cell and Molecular Biology·George D LeikaufJames P Fabisiak
Mar 25, 2006·The Journal of Clinical Investigation·John J LeporeMichael S Parmacek
Jul 29, 2010·The Journal of Clinical Investigation·Andrea CasazzaLuca Tamagnone
Jul 29, 2010·The Journal of Clinical Investigation·Michael Klagsbrun, Akio Shimizu
Dec 16, 2010·The Journal of Clinical Investigation·Rajan JainJonathan A Epstein
Apr 21, 2011·The Journal of Clinical Investigation·Yoko FukushimaAkiyoshi Uemura
Oct 17, 2007·BMC Developmental Biology·Yolanda AlvarezBreandan N Kennedy
Nov 10, 2010·BMC Cancer·Shuangmei YeShixuan Wang
Apr 6, 2006·Genome Biology·Umar Yazdani, Jonathan R Terman

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