PlexinD1 is required for proper patterning of the periocular vascular network and for the establishment of corneal avascularity during avian ocular development

Developmental Biology
Sam KwiatkowskiPeter Y Lwigale

Abstract

The anterior eye is comprised of an avascular cornea surrounded by a dense periocular vascular network and therefore serves as an excellent model for angiogenesis. Although signaling through PlexinD1 underlies various vascular patterning events during embryonic development, its role during the formation of the periocular vascular network is yet to be determined. Our recent study showed that PlexinD1 mRNA is expressed by periocular angioblasts and blood vessels during ocular vasculogenesis in patterns that suggest its involvement with Sema3 ligands that are concurrently expressed in the anterior eye. In this study, we used in vivo knockdown experiments to determine the role of PlexinD1 during vascular patterning in the anterior eye of the developing avian embryos. Knockdown of PlexinD1 in the anterior eye caused mispatterning of the vascular network in the presumptive iris, which was accompanied by lose of vascular integrity and profuse hemorrhaging in the anterior chamber. We also observed ectopic vascularization of the cornea in PlexinD1 knockdown eyes, which coincided with the formation of the limbal vasculature in controls. Finally we show that Sema3E and Sema3C transcripts are expressed in ocular tissue that is devoid of va...Continue Reading

References

Nov 1, 1978·Investigative Ophthalmology & Visual Science·J G Cumha-Vaz
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·L P AielloL E Smith
Apr 27, 2002·Texas Medicine·Joan L Kelly, Preston H Blomquist
Sep 17, 2002·Current Opinion in Cell Biology·Shoichiro Tsukita, Mikio Furuse
Dec 4, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·John K Chilton, Sarah Guthrie
Jul 9, 2004·Developmental Cell·Jesús Torres-VázquezBrant M Weinstein
Jul 28, 2004·Investigative Ophthalmology & Visual Science·David Hui-Kang MaJan-Kan Chen
May 21, 2005·The International Journal of Developmental Biology·Sophie CreuzetGérard Couly
Nov 3, 2005·Developmental Biology·Peter Y LwigaleMarianne Bronner-Fraser
Aug 31, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nazifa BanuAlda Tufro
Sep 26, 2006·Journal of Cellular Physiology·Sumio OhtsukiTetsuya Terasaki
Dec 8, 2006·The British Journal of Ophthalmology·Balamurali K AmbatiRuth Caldwell
Jul 16, 2008·Developmental Biology·Toshihiko ToyofukuHitoshi Kikutani
Jan 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Azeb Tadesse ArgawGareth R John
Feb 28, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Irina V LarinaMary E Dickinson
May 9, 2009·Developmental Biology·Ryan E LamontSarah J Childs
May 14, 2009·Seminars in Ophthalmology·Pauline LimUla V Jurkunas
Jan 27, 2010·Progress in Retinal and Eye Research·David EllenbergJin-Hong Chang
Mar 20, 2010·Experimental Eye Research·Xi Han, Ming-Chang Zhang
Jun 25, 2010·Clinical & Experimental Ophthalmology·Naoyuki MorishigeTeruo Nishida
Oct 1, 2010·Developmental Biology·Carl M GayJesús Torres-Vázquez
Apr 21, 2011·The Journal of Clinical Investigation·Yoko FukushimaAkiyoshi Uemura
Aug 2, 2011·Developmental Cell·Tomasz ZygmuntJesús Torres-Vázquez
Feb 22, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Karyn Jourdeuil, Tamara A Franz-Odendaal
Aug 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Juan E FerrarioSarah Guthrie
Aug 29, 2012·Cancer Science·Hideyo MiyatoJoji Kitayama
Nov 7, 2012·Progress in Retinal and Eye Research·Thomas F Freddo
Dec 29, 2012·Seminars in Cell & Developmental Biology·Won-Jong Oh, Chenghua Gu
Feb 28, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Stryder M MeadowsOndine Cleaver
Feb 28, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sam KwiatkowskiPeter Y Lwigale
May 30, 2013·American Journal of Respiratory Cell and Molecular Biology·Stephen JozaMartin Post
Jun 4, 2013·Gene Expression Patterns : GEP·Ana F OjedaPeter Y Lwigale
Sep 5, 2013·Investigative Ophthalmology & Visual Science·James W Spurlin, Peter Y Lwigale
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.