Plexus and peripheral nerve metastasis

Handbook of Clinical Neurology
Kelly G Gwathmey

Abstract

Cancer in the form of solid tumors, leukemia, and lymphoma can infiltrate and metastasize to the peripheral nervous system, including the cranial nerves, nerve roots, cervical, brachial and lumbosacral plexuses, and, rarely, the peripheral nerves. This review discusses the presentation, diagnostic evaluation, and treatment options for metastatic lesions to these components of the peripheral nervous system and is organized based on the anatomic distribution. As skull base metastases (also discussed in Chapter 14) result in cranial neuropathies, these will be covered in detail, as well as cancers that directly infiltrate the cranial nerves. Particular emphasis is placed on the clinical, imaging, and electrodiagnostic features that differentiate neoplastic plexopathies from radiation-induced plexopathies. Neurolymphomatosis, in which malignant lymphocytes invade the cranial nerves, nerve roots, brachial and lumbosacral plexuses, and peripheral nerves, is a rare manifestation of lymphoma and leukemia. Diagnoses of neurolymphomatosis are often missed or delayed given its varied presentations, resulting in poorer outcomes. Thus this disease will also be discussed in depth.

Citations

Dec 18, 2018·Journal of the Peripheral Nervous System : JPNS·Chiara BrianiFrancesco Piazza
Oct 2, 2020·Continuum : Lifelong Learning in Neurology·Zachary N London
Apr 29, 2019·Current Treatment Options in Neurology·Elena ShaninaRobert Glenn Smith
Sep 29, 2020·Journal of Neuromuscular Diseases·Josef FinstererStefan Iglseder
Jan 16, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·B FianiL Delgado
Jun 24, 2021·Revista española de medicina nuclear e imagen molecular·Kevser OksuzogluTanju Yusuf Erdil

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