Plexus-Specific Detection of Retinal Vascular Pathologic Conditions with Projection-Resolved OCT Angiography

Ophthalmology Retina
Rachel C PatelYali Jia

Abstract

To evaluate the projection-resolved (PR) optical coherence tomography angiography (OCTA) algorithm in detecting plexus-specific vascular abnormalities in retinal pathologies. Cross-sectional observational clinical study. Patients diagnosed with retinal vascular diseases and healthy volunteers. Eyes were imaged using an OCT system operating at 840 nm and employing the split-spectrum amplitude decorrelation algorithm. A novel algorithm suppressed projection artifacts inherent to OCTA. The volumetric scans were segmented and visualized on different plexuses. Qualitative observation of vascular abnormalities on both cross-sectional and en face PR-OCTA images. Eight illustrative cases are reported. In cases of diabetic retinopathy, retinal vessel occlusion, and retinitis pigmentosa, PR-OCTA detected retinal nonperfusion regions within deeper retinal plexuses not visualized by conventional OCTA. In age-related macular degeneration, cross-sectional PR-OCTA permitted the classification of choroidal neovascularization, and, in a case of retinal angiomatous proliferation, identified a vertical vessel contiguous with the deep capillary plexus. In macular telangiectasia, PR-OCTA detected a diving perifoveal vein and delineated subretinal n...Continue Reading

References

Oct 1, 1996·American Journal of Ophthalmology·J E GrunwaldJ Dupont
Mar 30, 2002·Acta Ophthalmologica Scandinavica. Supplement·Marianne Haim
Apr 14, 2004·Archives of Ophthalmology·David S FriedmanUNKNOWN Eye Diseases Prevalence Research Group
Apr 28, 2004·JAMA : the Journal of the American Medical Association·Neil M Bressler
Nov 23, 2006·Lancet·Dyonne T HartongThaddeus P Dryja
Mar 11, 2008·Retina·Lawrence A YannuzziBeatriz S Takahashi
Jun 10, 2008·Investigative Ophthalmology & Visual Science·Ning CheungTien Yin Wong
Jul 21, 2012·Investigative Ophthalmology & Visual Science·Geoffrey ChanDao-Yi Yu
Oct 11, 2012·Ophthalmology·Gui-shuang YingUNKNOWN Comparison of Age-related Macular Degeneration Treatments Trials Research Group
Dec 12, 2012·Progress in Retinal and Eye Research·Peter Charbel IssaHendrik P N Scholl
Feb 15, 2013·Documenta Ophthalmologica. Advances in Ophthalmology·Yi ZhangTimothy Q Duong
Jan 24, 2015·Expert Opinion on Biological Therapy·Andrew ZhengStephen H Tsang
Apr 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yali JiaDavid Huang
Jul 27, 2015·American Journal of Ophthalmology·Sankha AmarakoonJohannes F de Boer
Oct 3, 2015·Retina·Richard F SpaideNadia K Waheed
Oct 13, 2015·Retina·Marco A Bonini FilhoNadia K Waheed
Nov 26, 2015·Ophthalmic Surgery, Lasers & Imaging Retina·Alexander H de Castro-AbegerCaroline R Baumal
Nov 27, 2015·Expert Review of Ophthalmology·Cristy A Ku, Mark E Pennesi
Feb 16, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Talisa E de CarloElias Reichel
May 28, 2016·Biomedical Optics Express·Miao ZhangYali Jia

❮ Previous
Next ❯

Citations

Feb 14, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Dawei YangJin Zeng
Aug 3, 2020·Ophthalmology and Therapy·Enrico BorrelliGiuseppe Querques
Mar 15, 2019·Ophthalmology and Therapy·Enrico BorrelliGiuseppe Querques
Oct 6, 2020·Biomedical Optics Express·Min GaoYali Jia
Mar 27, 2021·Progress in Retinal and Eye Research·Tristan T HormelYali Jia
Mar 31, 2021·American Journal of Ophthalmology·Gilda CennamoMaria Triassi
Jun 25, 2021·Progress in Retinal and Eye Research·Ursula Schmidt-ErfurthHrvoje Bogunović
Jul 10, 2021·Annual Review of Vision Science·Alexi GeevargheseJoel S Schuman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.