PLGA Microspheres Incorporated Gelatin Scaffold: Microspheres Modulate Scaffold Properties.

International Journal of Biomaterials
Indranil BanerjeeTapas K Maiti

Abstract

Freeze drying is one of the popular methods of fabrication for poly(lactide-co-glycolide) (PLGA) microspheres incorporated polymer scaffolds. However, the consequence of microspheres incorporation on physical and biological properties of scaffold has not been studied yet. In this study, attempt has been made to characterize the effect of PLGA microsphere incorporation on the physical properties of freeze-dried gelatin scaffold and its influence on cytocompatibility. Scaffolds loaded with varying amount of PLGA microspheres (10%, 1%, 0.1% w/w) were subjected to microarchitecture analysis, swelling, porosity, mechanical properties, biodegradation, cell adhesion, and cell proliferation studies. Results revealed that an increase in percentage loading of microspheres reduced the pore size and uniformity of the pore structure. Moreover, loading of PLGA microspheres up to 1% w/w significantly increased porosity, swelling, and mechanical properties of the scaffold but variations were not proportional for 10% w/w loading. Results also showed that PLGA microspheres have no significant effect on cell adhesion but influenced the growth kinetics.

References

Dec 9, 1983·Science·R Wolfenden
May 20, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·D A NorrisP J Sinko
Jun 26, 1999·Biomaterials·S V Madihally, H W Matthew
Jul 14, 1999·Biomaterials·H W KangY Ikada
Jun 6, 2000·Advanced Drug Delivery Reviews·M S Shive, J M Anderson
Nov 2, 2001·Nature Biotechnology·T P RichardsonD J Mooney
Aug 19, 2003·Biomaterials·Jeanie L Drury, David J Mooney
Sep 1, 2004·International Journal of Pharmaceutics·S Freiberg, X X Zhu
Nov 24, 2004·Journal of Biomaterials Science. Polymer Edition·Sara M RoyceKacey G Marra
Jul 12, 2005·Biomaterials·Yan HuangSundararajan V Madihally
Dec 6, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alex GoraltchoukMolly S Shoichet
Aug 31, 2006·Journal of Biomedical Materials Research. Part a·Alicia J DefailKacey G Marra

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Citations

Mar 4, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Hemlata ChhabraJayesh R Bellare
May 31, 2014·Tissue Engineering. Part a·Kathleen M McAndrewsMichelle R Dawson
Jul 26, 2011·Journal of the Mechanical Behavior of Biomedical Materials·Vijay Kumar NandagiriGianluca Ciardelli
May 22, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Mohammad MehrasaAyyoob Arpanaei
May 24, 2016·International Journal of Biological Macromolecules·Jeevithan ElangoJeya Shakila Robinson
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Farnaz GhorbaniAli Zamanian
Jul 28, 2016·International Journal of Biological Macromolecules·Daniel Enrique López Angulo, Paulo José do Amaral Sobral
Sep 23, 2016·The AAPS Journal·Sheetal D'MelloAliasger K Salem
Oct 19, 2016·Journal of Biomedical Materials Research. Part a·Soher Nagi JayashN A Baharuddin
Mar 2, 2017·Biotechnology Progress·Seung Hwan LeeJong Hwan Sung
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Piergiorgio GentileZebunnissa Ramtoola
Mar 7, 2020·Polymers·Dorota KołbukOlga Urbanek
Jan 14, 2019·ACS Biomaterials Science & Engineering·Arijit Bhattacharjee, Dhirendra S Katti

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Methods Mentioned

BETA
scanning electron microscopy

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