PLGA nanoparticles as chlorhexidine-delivery carrier to resin-dentin adhesive interface

Dental Materials : Official Publication of the Academy of Dental Materials
B M PriyadarshiniAmr S Fawzy

Abstract

To characterize and deliver fabricated CHX-loaded PLGA-nanoparticles inside micron-sized dentinal-tubules of demineralized dentin-substrates and resin-dentin interface. Nanoparticles fabricated by emulsion evaporation were assessed in-vitro by different techniques. Delivery of drug-loaded nanoparticles to demineralized dentin substrates, interaction with collagen matrix, and ex-vivo CHX-release profiles using extracted teeth connected to experimental setup simulating pulpal hydrostatic pressure were investigated. Furthermore, nanoparticles association/interaction with a commercial dentin-adhesive applied to demineralized dentin substrates were examined. The results showed that the formulated nanoparticles demonstrated attractive physicochemical properties, low cytotoxicity, potent antibacterial efficacy, and slow degradation and gradual CHX release profiles. Nanoparticles delivered efficiently inside dentinal-tubules structure to sufficient depth (>10μm) against the simulated upward pulpal hydrostatic-pressure, even after bonding-resins infiltration and were attached/retained on collagen-fibrils. These results verified the potential significance of this newly introduced drug-delivery therapeutic strategy for future clinical app...Continue Reading

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Citations

Dec 2, 2019·Journal of Materials Science. Materials in Medicine·Lívia Rodrigues de MenezesMarina Rodrigues Tavares
Jan 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingou LiangLei Cheng
Jan 8, 2020·Polymers·Pierre PouponneauAntoine Alves
Feb 14, 2021·Dental Materials : Official Publication of the Academy of Dental Materials·Yanwei YangZengjie Fan
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Zohaib AkramAmr S Fawzy
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Jian YuCui Huang
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valeria MercadanteAlessandro Poma
Aug 2, 2021·International Journal of Pharmaceutics·Matteo MaraldiDavide Moscatelli
Feb 23, 2019·Journal of Dentistry·Ana Helena Schauenberg MachadoFabrício Mezzomo Collares
May 26, 2018·ACS Applied Materials & Interfaces·Nancy C AndrésPaula V Messina

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