PlGF Immunological Impact during Pregnancy.

International Journal of Molecular Sciences
Loredana AlboniciRoberto Bei

Abstract

During pregnancy, the mother's immune system has to tolerate the persistence of paternal alloantigens without affecting the anti-infectious immune response. Consequently, several mechanisms aimed at preventing allograft rejection, occur during a pregnancy. In fact, the early stages of pregnancy are characterized by the correct balance between inflammation and immune tolerance, in which proinflammatory cytokines contribute to both the remodeling of tissues and to neo-angiogenesis, thus, favoring the correct embryo implantation. In addition to the creation of a microenvironment able to support both immunological privilege and angiogenesis, the trophoblast invades normal tissues by sharing the same behavior of invasive tumors. Next, the activation of an immunosuppressive phase, characterized by an increase in the number of regulatory T (Treg) cells prevents excessive inflammation and avoids fetal immuno-mediated rejection. When these changes do not occur or occur incompletely, early pregnancy failure follows. All these events are characterized by an increase in different growth factors and cytokines, among which one of the most important is the angiogenic growth factor, namely placental growth factor (PlGF). PlGF is initially isol...Continue Reading

References

Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D MaglioneM G Persico
Dec 17, 1997·The American Journal of Cardiology·J F Clapp, E Capeless
Aug 26, 1998·The Journal of Biological Chemistry·M MigdalG Neufeld
May 3, 2002·The Journal of Biological Chemistry·Roni MamlukMichael Klagsbrun
Aug 2, 2002·Biochemical and Biophysical Research Communications·Aernout LuttunLieve Moons
Sep 5, 2002·Nature Reviews. Immunology·Ashley Moffett-King
Mar 5, 2003·Advances in Experimental Medicine and Biology·Gera NeufeldYael Herzog
Oct 3, 1953·Nature·R E BILLINGHAMP B MEDAWAR
Feb 6, 2004·Nature Immunology·Varuna R AluvihareAlexander G Betz
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Ravi ThadhaniS Ananth Karumanchi
Feb 7, 2004·The New England Journal of Medicine·Richard J LevineS Ananth Karumanchi
Dec 21, 2004·Molecular Immunology·Alessandra ZingoniLewis L Lanier
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mikhail M DikovDavid P Carbone
Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier
Jun 2, 2005·Nature Reviews. Immunology·Fernando Macian
Sep 3, 2005·Immunological Investigations·Marianne J van den HeuvelB Anne Croy
Oct 6, 2005·Journal of Leukocyte Biology·Chandrakant TayadeB Anne Croy
Feb 17, 2006·Nature Immunology·John Trowsdale, Alexander G Betz
Jul 4, 2006·Journal of Leukocyte Biology·Gendie E LashJudith N Bulmer
Sep 9, 2006·Nature Medicine·Philippe Le Bouteiller, Julie Tabiasco
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chandrakant TayadeB Anne Croy
Apr 3, 2007·Immunity·Mathias LucasAndreas Diefenbach
Apr 27, 2007·Clinical and Experimental Immunology·Y SasakiS Saito
May 11, 2007·Journal of Reproductive Immunology·Hernan D Kopcow, S Ananth Karumanchi
Jun 2, 2007·Cell Death and Differentiation·A MorettaL Moretta
Jun 15, 2007·American Journal of Reproductive Immunology : AJRI·Alpana SharmaJai Bhagwan Sharma
Sep 19, 2007·The Journal of Experimental Medicine·Tomasz J GuzikDavid G Harrison
Jan 15, 2008·American Journal of Physiology. Heart and Circulatory Physiology·George OsolKarolina Kublickiene
Jan 26, 2008·Clinical Reviews in Allergy & Immunology·Miri Blank, Yehuda Shoenfeld

❮ Previous
Next ❯

Citations

Aug 8, 2021·International Journal of Molecular Sciences·Andrea Olmos-OrtizVerónica Zaga-Clavellina

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Hamid Reza NejabatiMohammad Nouri
Nihon rinsho. Japanese journal of clinical medicine
Shiro Uemura, Yoshihiko Saito
Oncotarget
Daniela Carnevale, Giuseppe Lembo
Gynäkologisch-geburtshilfliche Rundschau
Markus SchmidtSabine Kasimir-Bauer
© 2021 Meta ULC. All rights reserved