PLK-1: Angel or devil for cell cycle progression

Biochimica Et Biophysica Acta
Shiv KumarJaebong Kim

Abstract

PLK-1 is a key player in the eukaryotic cell cycle. Cell cycle progression is precisely controlled by cell cycle regulatory kinases. PLK-1 is a mitotic kinase that actively regulates the G2/M transition, mitosis, mitotic exit, and cytokinesis. During cell cycle progression, PLK-1 controls various events related to the cell cycle maturation, directly and/or indirectly. On the contrary, aberrant expression of PLK-1 is strongly associated with tumorigenesis and its poor prognosis. The misexpression of PLK-1 causes the abnormalities including aneuploidy, mitotic defects, leading to tumorigenesis through inhibiting the p53 and pRB genes. Therefore, we reviewed the role of PLK-1 in the cell cycle progression and in the tumorigenesis either as a cell cycle regulator or on an attractive anti-cancer drug target.

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Citations

Nov 11, 2016·Cell Cycle·Alfonso ParrillaAnna Santamaria
Feb 19, 2019·Oral Diseases·Jaijam SuwanwelaThanaphum Osathanon
Mar 6, 2021·Cell & Bioscience·Qi WuSi Sun
Jun 26, 2021·Biotechnology and Bioengineering·Shahin AghamiriHossein Ghanbarian
Aug 30, 2021·Biochemical Pharmacology·Styliani IliakiInna S Afonina

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