pLoc_bal-mGpos: Predict subcellular localization of Gram-positive bacterial proteins by quasi-balancing training dataset and PseAAC

Genomics
Xuan XiaoKuo-Chen Chou

Abstract

Knowledge of protein subcellular localization is vitally important for both basic research and drug development. With the avalanche of protein sequences emerging in the post-genomic age, it is highly desired to develop computational tools for timely and effectively identifying their subcellular localization purely based on the sequence information alone. Recently, a predictor called "pLoc-mGpos" was developed for identifying the subcellular localization of Gram-positive bacterial proteins. Its performance is overwhelmingly better than that of the other predictors for the same purpose, particularly in dealing with multi-label systems in which some proteins, called "multiplex proteins", may simultaneously occur in two or more subcellular locations. Although it is indeed a very powerful predictor, more efforts are definitely needed to further improve it. This is because pLoc-mGpos was trained by an extremely skewed dataset in which some subset (subcellular location) was over 11 times the size of the other subsets. Accordingly, it cannot avoid the bias consequence caused by such an uneven training dataset. To alleviate such bias consequence, we have developed a new and bias-reducing predictor called pLoc_bal-mGpos by quasi-balancin...Continue Reading

Citations

Jun 13, 2019·Current Medicinal Chemistry·Cong Bao Kang
Oct 28, 2019·Current Topics in Medicinal Chemistry·Kuo-Chen Chou
Nov 8, 2019·Current Pharmaceutical Design·Yuan ZhangHongying Hou
Nov 30, 2019·Current Pharmaceutical Design·Kuo-Chen Chou
Sep 22, 2018·Molecular Biology Reports·Ahmad Hassan ButtYaser Daanial Khan
Aug 18, 2020·BioMed Research International·Feng-Min Li, Xiao-Wei Gao
Oct 13, 2018·Molecular Biology Reports·Yaser Daanial KhanKuo-Chen Chou
Oct 21, 2019·Current Topics in Medicinal Chemistry·Jianqiang LanJianyong Li
Jan 3, 2020·Molecular Genetics and Genomics : MGG·Kuo-Chen Chou
Dec 6, 2019·Database : the Journal of Biological Databases and Curation·Lei ZhengYongchun Zuo
May 18, 2020·The Journal of Membrane Biology·Adeel Ur RehmanKhalid Khan
Apr 6, 2019·Current Medicinal Chemistry·Qingjun PanHua-Feng Liu

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