Ploidy as a prognostic indicator in oesophageal squamous carcinoma and its relationship to various histological criteria

The Journal of Pathology
J M EdwardsP S Hasleton


One hundred surgically resected squamous cell carcinomas of the oesophagus were studied retrospectively to assess the significance of DNA aneuploidy as determined by flow cytometry using paraffin-embedded tissue. DNA aneuploidy was not an independent prognostic indicator but was found to be associated with tumour necrosis and host/tumour interface fibrosis. When tumours confined to submucosa or muscle wall were assessed, diploid tumours had a poorer survival rate than DNA aneuploid tumours. Other histological variables studied were tumour differentiation, depth of infiltration, glandular and small cell differentiation, lymphatic and vascular spread and host inflammatory response. These failed to show any significant association with ploidy.


Jun 1, 1986·The Journal of Pathology·P Quirke, J E Dyson
Oct 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D E MerkelW L McGuire
Jan 1, 1988·The British Journal of Surgery·D J JonesP F Schofield
Jan 1, 1988·Journal of Clinical Pathology·C E BlomjousC J Meyer
Apr 1, 1988·Journal of Clinical Pathology·K G MorganC C Bird
Mar 1, 1988·Thorax·D J JonesM Moore
Apr 1, 1986·Journal of Clinical Pathology·H S Goh, J R Jass
Oct 1, 1986·British Journal of Cancer·D R MorganC C Bird
Dec 1, 1986·Gut·J B FozardC C Bird
Sep 1, 1984·Journal of Clinical Pathology·M L FriedlanderI W Taylor
Nov 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D W HedleyE A Musgrove
Feb 1, 1984·British Journal of Cancer·M L FriedlanderM H Tattersall

❮ Previous
Next ❯


May 1, 1994·World Journal of Surgery·H IdeF Hanyu
Feb 1, 1992·Surgical Oncology·T N WalshT P Hennessy
Sep 13, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J M FindlayI Tomlinson
Aug 1, 1991·The British Journal of Surgery·P H TheunissenD C Poortvliet
Apr 7, 2005·Digestive Diseases and Sciences·Shazia RafiqMichael D Sitrin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.