Ploidy Leads a Molecular Motor to Walk Different Paths to Drug Resistance.

Cell Chemical Biology
Alexander M RealArvin C Dar

Abstract

In this issue of Cell Chemical Biology, Pisa et al. (2020) find that haploid and diploid cells differentially develop resistance to the CENP-E inhibitor GSK923295. The results highlight the power of tumor cells to evade growth inhibition and potentially inform the design of next-generation CENP-E drugs to overcome resistance.

References

Dec 27, 2006·Cancer Cell·Beth A A WeaverDon W Cleveland
Feb 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kenneth W WoodJeffrey R Jackson
May 10, 2011·Annual Review of Biochemistry·Arvin C Dar, Kevan M Shokat
Mar 20, 2012·Cell·Michael S Glickman, Charles L Sawyers
Jul 31, 2013·Journal of Molecular Biology·Vivek MusinipallyEva Nogales
Mar 23, 2017·Nature·Andrew A WylieWilliam R Sellers
Oct 19, 2017·Trends in Pharmacological Sciences·Tarun M Kapoor, Rand M Miller
Feb 20, 2019·Nature Chemical Biology·Tommaso CupidoTarun M Kapoor
Jul 2, 2019·Cell Chemical Biology·Rudolf PisaTarun M Kapoor

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