Plumbagin Increases Paclitaxel-Induced Cell Death and Overcomes Paclitaxel Resistance in Breast Cancer Cells through ERK-Mediated Apoptosis Induction

Journal of Natural Products
Anna KawiakEwa Lojkowska

Abstract

ERK is a component of mitogen-activated protein kinases that controls a range of cellular processes including cell proliferation and survival. The upregulation of ERK has been associated with apoptosis inhibition in response to various stimuli including chemotherapeutic agents. Research has suggested that the upregulation of ERK signaling by the anticancer agent paclitaxel leads to acquired resistance of cells to this compound. The presented research focused on determining the role of plumbagin, a naturally derived naphthoquinone, in the sensitization of breast cancer cells to paclitaxel-induced cell death and the involvement of ERK signaling in this process. The results of the study indicated that plumbagin increases the sensitivity of breast cancer cells to paclitaxel. Moreover, a synergistic effect between plumbagin and paclitaxel was observed. Plumbagin was shown to decrease levels of phosphorylated ERK in breast cancer cells and abrogated paclitaxel-induced ERK phosphorylation. The role of ERK in plumbagin-mediated sensitization of breast cancer cells to paclitaxel was shown through the enhancement of the synergistic effect between compounds in cells with decreased ERK expression. Furthermore, plumbagin reduced p-ERK level...Continue Reading

References

Aug 1, 1990·Journal of the National Cancer Institute·E K RowinskyR C Donehower
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·A A ReszkaE H Fischer
Oct 20, 2000·The Journal of Biological Chemistry·J P MacKeiganJ P Ting
Apr 24, 2001·Genes & Development·A SchulzeJ Downward
Jan 2, 2003·Nature Reviews. Cancer·Julian Downward
Nov 7, 2006·IUBMB Life·Zhimin Lu, Shuichan Xu
Jul 10, 2007·Toxicology and Applied Pharmacology·Anna KawiakEwa Lojkowska
Oct 11, 2008·Cell Death and Differentiation·K Balmanno, S J Cook
Feb 13, 2010·Journal of Hematology & Oncology·Christophe Frémin, Sylvain Meloche
Jul 19, 2012·International Journal of Cancer. Journal International Du Cancer·Sutapa SinhaPriya Srinivas
Mar 15, 2018·BMC Complementary and Alternative Medicine·Haiting ChenJingxue Ma
Aug 7, 2018·Biotechnology Advances·Atanas G AtanasovMaciej Banach

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Citations

Jul 1, 2020·FEBS Open Bio·Di Yu-WeiYou-Wei Zheng
Dec 22, 2020·BioMed Research International·Zhenhua YinWenyi Kang
May 9, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ze-Bo JiangElaine Lai-Han Leung

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