Plumbagin Nanoparticles Induce Dose and pH Dependent Toxicity on Prostate Cancer Cells

Current Drug Delivery
Harikrishnan A NairVinoth-Kumar Lakshmanan

Abstract

Stable nano-formulation of Plumbagin nanoparticles from Plumbago zeylanica root extract was explored as a potential natural drug against prostate cancer. Size and morphology analysis by DLS, SEM and AFM revealed the average size of nanoparticles prepared was 100±50nm. In vitro cytotoxicity showed concentration and time dependent toxicity on prostate cancer cells. However, plumbagin crude extract found to be highly toxic to normal cells when compared to plumbagin nanoformulation, thus confirming nano plumbagin cytocompatibility with normal cells and dose dependent toxicity to prostate cells. In vitro hemolysis assay confirmed the blood biocompatibility of the plumbagin nanoparticles. In wound healing assay, plumbagin nanoparticles provided clues that it might play an important role in the anti-migration of prostate cancer cells. DNA fragmentation revealed that partial apoptosis induction by plumbagin nanoparticles could be expected as a potent anti-cancer effect towards prostate cancer.

Citations

Nov 5, 2016·Applied Biochemistry and Biotechnology·Anjusha MohanVinoth-Kumar Lakshmanan
Mar 10, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Haseeb ZubairAjay Pratap Singh
Nov 14, 2017·Chemical Biology & Drug Design·Han-Yue QiuYong-Hua Yang
Apr 1, 2017·The American Journal of Chinese Medicine·Yuling LiuHui Li
Jul 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Aya M ZakiHala F Zaki

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