Pluripotency Conversion of Gene Studied from Quantum Folding Theory

BioRxiv : the Preprint Server for Biology
Liaofu Luo


The chemically and physically induced pluripotency in a stem cell is studied from the point of quantum transition between differentiation and pluripotency states in genes. The quantum folding theory of a macromolecule is briefly reviewed. The relation of protein folding rate with the number N of torsion modes participating in the quantum transition (coherence degree) is discussed and a simple statistical relationship is obtained. As a unifying approach to conformational quantum transition the folding rate formula can be generalized from protein to nucleic acid. It is found that the formula of folding rate versus N well fits RNA folding data. Then the quantum folding theory is applied to study the pluripotency conversion in stem cell. We proved that the acquisition of pluripotency is essentially a quantum-stochastic event of small-probability through the comparison of the rate with protein folding. Due to the large coherence degree of DNA and the uphill nature of torsion transition the pluripotency-acquisition rate should be small. By establishing the reaction network of the conformational change of the pluripotency genes the characteristic time of the chemical reprogramming is calculated and the result is consistent with experi...Continue Reading

Related Concepts

Cell Differentiation Process
Nucleic Acids
Stem Cells
Vocal Cord Structure
Protein Folding

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.