Pluripotency Factors on Their Lineage Move

Stem Cells International
Clair E WeidgangMartin Mueller

Abstract

Pluripotent stem cells are characterised by continuous self-renewal while maintaining the potential to differentiate into cells of all three germ layers. Regulatory networks of maintaining pluripotency have been described in great detail and, similarly, there is great knowledge on key players that regulate their differentiation. Interestingly, pluripotency has various shades with distinct developmental potential, an observation that coined the term of a ground state of pluripotency. A precise interplay of signalling axes regulates ground state conditions and acts in concert with a combination of key transcription factors. The balance between these transcription factors greatly influences the integrity of the pluripotency network and latest research suggests that minute changes in their expression can strengthen but also collapse the network. Moreover, recent studies reveal different facets of these core factors in balancing a controlled and directed exit from pluripotency. Thereby, subsets of pluripotency-maintaining factors have been shown to adopt new roles during lineage specification and have been globally defined towards neuroectodermal and mesendodermal sets of embryonic stem cell genes. However, detailed underlying insig...Continue Reading

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Citations

May 31, 2020·Journal of Clinical Periodontology·Mohamed MekhemarKarim Fawzy El-Sayed
Apr 18, 2019·In Vitro Cellular & Developmental Biology. Animal·Daisuke TakekoshiHidemasa Kato
May 21, 2021·Reproduction in Domestic Animals = Zuchthygiene·Piyathip SetthawongTheerawat Tharasanit
Jul 3, 2021·International Journal of Molecular Sciences·Sonia LópezHiginio Arzate

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