Pluripotent Stem Cells: Current Understanding and Future Directions

Stem Cells International
Antonio Romito, Gilda Cobellis

Abstract

Pluripotent stem cells have the ability to undergo self-renewal and to give rise to all cells of the tissues of the body. However, this definition has been recently complicated by the existence of distinct cellular states that display these features. Here, we provide a detailed overview of the family of pluripotent cell lines derived from early mouse and human embryos and compare them with induced pluripotent stem cells. Shared and distinct features of these cells are reported as additional hallmark of pluripotency, offering a comprehensive scenario of pluripotent stem cells.

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Methods Mentioned

BETA
immunoprecipitation
ChIP-seq

Clinical Trials Mentioned

NCT01217008
NCT02302157
NCT01345006
NCT01344993
NCT02122159
NCT01691261
NCT02286089
NCT01674829
NCT02239354
NCT02057900

Software Mentioned

Ocata

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