Pluripotential rabbit embryonic stem (ES) cells are capable of forming overt coat color chimeras following injection into blastocysts

Molecular Reproduction and Development
L SchoonjansR W Moreadith

Abstract

The isolation of pluripotent embryonic stem (ES) cell lines from preimplantation rabbit embryos and their in vitro properties have been previously described. In the present investigation, these ES cell lines were further characterized and their capacity to contribute to formation of adult, fertile animals upon injection into recipient New Zealand White blastocysts demonstrated. The efficiency of chimera formation was low (5% of live born), but the degree of chimerism, as assessed by coat color contribution from the Dutch belted strain, was high (10-50%). Thus a significant step is taken toward the development of gene-targeting technology in the rabbit, an animal whose physiology and size lend itself to unique applications in biomedical research.

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Citations

Feb 18, 2009·Cloning and Stem Cells·Payungsuk IntawichaJyh-Cherng Ju
Jul 15, 2009·Cloning and Stem Cells·Disha Pant, Carol L Keefer
Sep 22, 2001·Cell Structure and Function·T Tada, M Tada
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Aug 29, 2012·Theriogenology·Z TancosA Dinnyes
Mar 7, 2014·The Veterinary Quarterly·Galbha DuggalPetra De Sutter
Jul 6, 2004·Molecular Reproduction and Development·Szilárd BodóZsuzsanna Bösze
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Jan 1, 2010·Biotechnology & Genetic Engineering Reviews·Gary AdamsNan Wang
Jan 5, 2002·Theriogenology·M B Wheeler, E M Walters

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