Plus disease in retinopathy of prematurity: development of composite images by quantification of expert opinion.

Investigative Ophthalmology & Visual Science
Michael F ChiangJohn T Flynn

Abstract

To demonstrate a methodology for generating composite wide-angle images of plus disease in retinopathy of prematurity (ROP), using quantitative analysis of expert opinions. Thirty-four wide-angle retinal images were independently interpreted by 22 ROP experts as "plus" or "not plus." All images were processed by the computer-based Retinal Image multiScale Analysis (RISA) system to calculate two parameters: arterial integrated curvature (AIC) and venous diameter (VD). Using a reference standard defined by expert consensus, sensitivity and specificity curves were calculated by varying the diagnostic cutoffs for AIC and VD. From these curves, individual vessels from multiple images were identified with particular diagnostic cutoffs, and were combined into composite wide-angle images using graphics-editing software. The values associated with 75% underdiagnosis of true plus disease (i.e., 25% sensitivity cutoff) were AIC 0.061 and VD 4.272, the values associated with 50% underdiagnosis of true plus disease (i.e., a 50% sensitivity cutoff) were AIC 0.049 and VD 4.088, and the values associated with 25% underdiagnosis of true plus disease (i.e., 75% sensitivity cutoff) were AIC 0.042 and VD 3.795. Composite wide-angle images were gen...Continue Reading

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Citations

Oct 12, 2010·International Ophthalmology Clinics·James D Reynolds
Dec 19, 2015·Ophthalmology·Ashkan M AbbeyMichael T Trese
Oct 21, 2009·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Michael F ChiangJohn T Flynn
Aug 12, 2009·Survey of Ophthalmology·Grace M RichterMichael F Chiang
Mar 4, 2011·Journal of Pediatric Ophthalmology and Strabismus·Leah A WittenbergMichael F Chiang
Nov 22, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Rany WooMichael F Chiang
Dec 5, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Michael T Trese
May 31, 2016·Ophthalmology·J Peter CampbellUNKNOWN Imaging & Informatics in Retinopathy of Prematurity Research Consortium
Oct 23, 2012·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Devon H GhodasraGraham E Quinn
Feb 7, 2018·Asia-Pacific Journal of Ophthalmology·Parag K ShahVenkatapathy Narendran
Jul 8, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tadashi MatsumotoYuichi Hori
Jul 25, 2020·Translational Vision Science & Technology·Brittni A ScruggsJ Peter Campbell
Sep 22, 2017·Japanese Journal of Ophthalmology·Tadashi MatsumotoYuichi Hori

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