PM10 in a background urban site: chemical characteristics and biological effects

Environmental Toxicology and Pharmacology
Tiziana SchiliròG Gilli

Abstract

PM10 was sampled in a background urban site in Torino, a northern Italian city. PM10 extracts were tested with THP-1 and A-549 cells to evaluate their effects on cell proliferation, LDH activity, TNFα, IL8 and CYP1A1 expression, and genotoxic damage induction (Comet assay). Through Principal Component Analysis (PCA), it was observed that (1) the aqueous extracts induced the inhibition of cell proliferation in the warm season that clustered together to total ions, (2) organic extracts determined a winter cell viability reduction and (3) there was a genotoxic effect associated with PAH and metal concentrations. The analysed low PAH levels were unable to induce significant CYP1A1 expression. The results obtained confirmed that PM composition and seasonality play an important role in particle-induced toxicity. The presence of PM10-induced biological effects at a low polluted site suggested that a reduction of PM10 mass did not seem to be sufficient to reduce its toxicity.

References

Mar 29, 2000·Environmental and Molecular Mutagenesis·R R TiceY F Sasaki
Jan 29, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M MorettiR Pasquini
Feb 6, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R B HetlandE Dybing
Mar 18, 2004·International Journal of Cancer. Journal International Du Cancer·Ad M KnaapenRoel P F Schins
Dec 2, 2004·Mutation Research·Larry D ClaxtonSarah H Warren
Dec 16, 2005·Environmental and Molecular Mutagenesis·Maria E Gutiérrez-CastilloPatricia Ostrosky-Wegman
Jun 30, 2006·Journal of the Air & Waste Management Association·Judith C Chow
Aug 19, 2007·The Science of the Total Environment·G GilliT Schilirò
Oct 4, 2007·Inhalation Toxicology·P E SchwarzeM Refsnes
Feb 8, 2008·Environment International·Anica SisovićVladimira Vadjić
Dec 6, 2008·Environmental Health Perspectives·Kristie L Ebi, Glenn McGregor
Apr 2, 2010·Environmental Science & Technology·Anton WesselsRoel P F Schins
May 12, 2010·Circulation·Robert D BrookUNKNOWN American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Coun
Mar 10, 2011·International Journal of Cancer. Journal International Du Cancer·Pallavi Lonkar, Peter C Dedon
Mar 1, 2010·Environmental Toxicology and Pharmacology·Tiziana SchiliròGiorgio Gilli
Dec 20, 2011·Toxicology Letters·Maurizio GualtieriCristina Battaglia
Dec 29, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Andrew J GhioMichael C Madden
Jan 17, 2012·Environmental Pollution·Elba Calesso TeixeiraFlavio Wiegand
Jan 22, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yu ShangYuan-Sheng Zang
Jan 11, 2014·Environmental Science and Pollution Research International·Luca AlessandriaGiorgio Gilli

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Citations

Jan 23, 2016·Environmental Science and Pollution Research International·L MegidoB Suárez-Peña
Mar 5, 2016·Journal of Toxicology and Environmental Health. Part a·Elisa Raquel A FerrazIsrael Felzenszwalb
Oct 17, 2018·Journal of Toxicology and Environmental Health. Part a·Marta GeaGiorgio Gilli
Jun 3, 2020·Scientific Reports·Alfredo SantovitoDeborah Traversi
Jul 2, 2020·International Journal of Environmental Research and Public Health·Ao DiXinlei Ge
Jun 3, 2021·International Journal of Environmental Research and Public Health·Claudia ZaniDonatella Feretti
Aug 8, 2021·Environmental Science and Pollution Research International·Tahereh RahmatiniaFarzad Fanaei

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