PM2.5 and survival among older adults: effect modification by particulate composition

Epidemiology
Marianthi-Anna KioumourtzoglouAntonella Zanobetti

Abstract

Fine particulate (PM2.5) air pollution has been consistently linked to survival, but reported effect estimates are geographically heterogeneous. Exposure to different types of particle mixtures may explain some of this variation. We used k-means cluster analyses to identify cities with similar pollution profiles, (ie, PM2.5 composition) across the United States. We examined the impact of PM2.5 on survival, and its variation across clusters of cities with similar PM2.5 composition, among Medicare enrollees in 81 US cities (2000-2010). We used time-varying annual PM2.5 averages, measured at ambient central monitoring sites, as the exposure of interest. We ran by-city Cox models, adjusting for individual data on previous cardiopulmonary-related hospitalizations and stratifying by follow-up time, age, gender, and race. This eliminates confounding by factors varying across cities and long-term trends, focusing on year-to-year variations of air pollution around its city-specific mean and trend. We then pooled the city-specific effects using a random effects meta-regression. In this second stage, we also assessed effect modification by cluster membership and estimated cluster-specific PM2.5 effects. We followed more than 19 million su...Continue Reading

References

Dec 9, 1993·The New England Journal of Medicine·D W DockeryF E Speizer
Oct 27, 2005·Journal of Exposure Science & Environmental Epidemiology·Philip K HopkeGeorge D Thurston
Aug 19, 2011·Environmental Health Perspectives·Bart OstroJordi Sunyer
Jan 15, 2014·Environmental Health : a Global Access Science Source·Marianthi-Anna KioumourtzoglouHelen Suh

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Citations

Feb 13, 2016·Environmental Science and Pollution Research International·Xiaobo LiRui Chen
Nov 26, 2015·Epidemiology·Marianthi-Anna KioumourtzoglouAntonella Zanobetti
Mar 25, 2016·Environmental Science & Technology·Jason WestChristine Wiedinmyer
Jun 29, 2016·Environmental Science and Pollution Research International·Wenjie ShanLanfang Cao
Nov 10, 2017·American Journal of Epidemiology·Ji-Young SonMichelle L Bell
Apr 30, 2016·Environmental Health Perspectives·Kyoung-Nam KimYun-Chul Hong
May 16, 2015·Environmental Health Perspectives·Marianthi-Anna KioumourtzoglouAntonella Zanobetti
May 16, 2019·Current Environmental Health Reports·Georgia PapadogeorgouAntonella Zanobetti
Sep 19, 2019·Journal of the Air & Waste Management Association·Minghui DiaoAmbarish Vaidyanathan
Jul 22, 2020·Environmental Science and Pollution Research International·Marija N TodorovićLjubiša M Ignjatović
Dec 19, 2019·International Journal of Environmental Research and Public Health·Keyao ChenXiaodong Liu
Sep 11, 2018·International Journal of Experimental Pathology·Laura Colín-BarenqueTeresa I Fortoul
May 10, 2019·Current Environmental Health Reports·Elizabeth A GibsonMarianthi-Anna Kioumourtzoglou
Apr 15, 2021·International Journal of Environmental Health Research·Robyn L PrueittJulie E Goodman
Jun 3, 2017·The Annals of Applied Statistics·Joshua P KellerAdam A Szpiro
Jun 29, 2021·Environmental Research·Yanelli NunezMarianthi-Anna Kioumourtzoglou

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