PMIDA-Modified Fe3 O4 Magnetic Nanoparticles: Synthesis and Application for Liver MRI

Langmuir : the ACS Journal of Surfaces and Colloids
Alexander M DeminLudmila M Ogorodova

Abstract

The surface modification of Fe3O4-based magnetic nanoparticles (MNPs) with N-(phosphonomethyl)iminodiacetic acid (PMIDA) was studied, and the possibility of their use as magnetic resonance imaging contrast agents was shown. The effect of the added PMIDA amount, the reaction temperature and time on the degree of immobilization of this reagent on MNPs, and the hydrodynamic characteristics of their aqueous colloidal solutions have been systematically investigated for the first time. It has been shown that the optimum condition for the modification of MNPs is the reaction at 40 °C with an equimolar amount of PMIDA for 3.5 h. The modified MNPs were characterized by X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric, and CHN elemental analyses. The dependence of the hydrodynamic characteristics of the MNP colloidal solutions on the concentration and pH of the medium was studied by the dynamic light scattering method. On the basis of the obtained data, we can assume that the PMIDA molecules are fixed on the surface of the MNPs as a monomolecular layer. The modified MNPs had good colloidal stability and high magnetic properties. The calculated relaxivities r2 and r1 were 341 ...Continue Reading

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Citations

Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chongchong MiaoHongchen Gu
Oct 24, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Alexandra G PershinaLudmila M Ogorodova
Jul 30, 2021·ACS Applied Materials & Interfaces·Alexander M DeminVictor P Krasnov
Nov 25, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Jincheng LiXuemei Wang

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