PML Nuclear Body Biogenesis, Carcinogenesis, and Targeted Therapy.

Trends in Cancer
Yuwen LiGuoyu Meng

Abstract

Targeted therapy has become increasingly important in cancer therapy. For example, targeting the promyelocytic leukemia PML protein in leukemia has proved to be an effective treatment. PML is the core component of super-assembled structures called PML nuclear bodies (NBs). Although this nuclear megaDalton complex was first observed in the 1960s, the mechanism of its assembly remains poorly understood. We review recent breakthroughs in the PML field ranging from a revised assembly mechanism to PML-driven genome organization and carcinogenesis. In addition, we highlight that oncogenic oligomerization might also represent a promising target in the treatment of leukemias and solid tumors.

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Citations

Apr 4, 2021·Veterinary Sciences·Sabari Nath Neerukonda
Apr 3, 2021·Biochemical and Biophysical Research Communications·Ying ZhangYunyun Geng
Jun 3, 2021·International Journal of Molecular Sciences·Alexander V FoninKonstantin K Turoverov
Oct 14, 2020·Developmental Cell·Ryan J EmeneckerLucia C Strader
Aug 8, 2021·International Journal of Molecular Sciences·Anudari MunkhjargalYong-Hwan Kim

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