PML nuclear body-residing proteins sequentially associate with HPV genome after infectious nuclear delivery

PLoS Pathogens
Lucile G M GuionMartin Sapp

Abstract

Subnuclear promyelocytic leukemia (PML) nuclear bodies (NBs) are targeted by many DNA viruses after nuclear delivery. PML protein is essential for formation of PML NBs. Sp100 and Small Ubiquitin-Like Modifier (SUMO) are also permanently residing within PML NBs. Often, large DNA viruses disassemble and reorganize PML NBs to counteract their intrinsic antiviral activity and support establishment of infection. However, human papillomavirus (HPV) requires PML protein to retain incoming viral DNA in the nucleus for subsequent efficient transcription. In contrast, Sp100 was identified as a restriction factor for HPV. These findings suggested that PML NBs are important regulators of early stages of the HPV life cycle. Nuclear delivery of incoming HPV DNA requires mitosis. Viral particles are retained within membrane-bound transport vesicles throughout mitosis. The viral genome is released from transport vesicles by an unknown mechanism several hours after nuclear envelope reformation. The minor capsid protein L2 mediates intracellular transport by becoming transmembranous in the endocytic compartment. Herein, we tested our hypothesis that PML protein is recruited to incoming viral genome prior to egress from transport vesicles. High-r...Continue Reading

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Citations

Feb 6, 2020·Viruses·Matthew Charman, Matthew D Weitzman
Mar 11, 2020·Frontiers in Cellular and Infection Microbiology·Lucile G Guion, Martin Sapp
Mar 7, 2021·Viruses·Ashley N Della FeraAlison A McBride
Jun 13, 2020·Trends in Cancer·Yuwen LiGuoyu Meng
Oct 19, 2019·Trends in Microbiology·Alessandra De LeoPaul M Lieberman
Mar 24, 2021·Cold Spring Harbor Perspectives in Biology·Bojana LucicMarina Lusic
Aug 14, 2021·Frontiers in Molecular Biosciences·Alison A McBrideSimran Khurana
Aug 21, 2021·Current Opinion in Virology·Michelle A Ozbun, Samuel K Campos

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Methods Mentioned

BETA
confocal microscopy
transfection
PCR

Software Mentioned

NIS Elements
Adobe Photoshop

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