PMX53 protects spinal cord from ischemia-reperfusion injury in rats in the short term

Spinal Cord
Q DongS Gong

Abstract

Experimental study. To investigate the effect of pre-treatment with PMX53, a C5aR antagonist, on spinal cord ischemia-reperfusion injury (IRI) in rat. Department of Neurosurgery, Second Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi Province, China. IRI was induced in the lumbar spinal cord by applying a mini aneurysm clamp to the abdominal aorta for 60 min in adult Sprague-Dawley rats. PMX53 (1 mg kg(-1)) was administered through femoral vein injection 30 min before ischemia on the rats in the PMX53 group (n=18). The saline group (n=18) was given saline at the same volume through femoral vein injection. The neurologic outcome of the posterior limbs was assessed by the Basso-Beattie-Bresnahan (BBB) score at 1, 6, 12, 24 and 48 h after reperfusion. Histologic changes of the spinal cord were detected with hematoxylin-eosin (H-E) staining. Enzyme-linked immunosorbent assay (ELISA) was used to detect myeloperoxidase (MPO) activity in the spinal cord. Immunohistochemistry was used to investigate the quantity of activated astrocytes and microglia. After pre-treatment with PMX53, neurologic function improved gradually after 6, 12, 24 and 48 h reperfusion. The BBB score of the PMX53 group increased si...Continue Reading

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Citations

Feb 9, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Andreza U Quadros, Thiago M Cunha
Feb 28, 2016·Respiratory Physiology & Neurobiology·Sara M F TurnerDavid D Fuller
Jul 6, 2017·Pharmaceuticals·Angela FaccendiniFranca Ferrari
Apr 1, 2020·The Journal of Spinal Cord Medicine·Kevser TuralIrfan Tasoglu
Sep 18, 2021·Journal of Neuropathology and Experimental Neurology·Hamdy AwadEsmerina Tili

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