PNA-directed solution- and surface-assembly of shell crosslinked (SCK) nanoparticle conjugates

Soft Matter
Jeffrey L TurnerKaren L Wooley

Abstract

The conjugation of complementary peptide nucleic acid (PNA) sequences to well defined shell crosslinked (SCK) nanoparticles is reported as a mechanism by which to direct their self assembly into higher order structures selective and tunable binding interactions. Base-pairing-driven aggregation of the SCK's occurred for mixtures of SCK's that presented complementary sequences in aqueous sodium chloride solutions and upon mica substrates. The assembly processes were monitored by dynamic light scattering and atomic force microscopy as a function of salt concentration, and by UV-vis spectroscopy as a function of salt concentration and temperature. Moreover, the stoichiometries of the PNA sequences conjugated per SCK nanoparticle and the stoichiometric ratios in the production of mixtures of SCK's bearing complementary PNA sequences were each altered to tune the hierarchical assemblies.

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Citations

Oct 24, 2006·Chemical Society Reviews·Rachel K O'ReillyKaren L Wooley
Jul 20, 2007·Chemical Communications : Chem Comm·Elizabeth S Read, Steven P Armes
Jan 15, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·E B PostnikovA Loskutov
Dec 31, 2020·Pharmaceuticals·Stefano VolpiRoberto Corradini
Jan 22, 2009·Journal of the American Chemical Society·Hamilton Kakwere, Sébastien Perrier
Aug 31, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Alessandro CalabrettaPascal Jonkheijm
Jan 11, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Hui ZhuYongming Chen
Nov 19, 2021·Chemical Society Reviews·Angela F De FazioAntonios G Kanaras
Mar 15, 2011·Colloids and Surfaces. B, Biointerfaces·A Nimrodh AnanthS Umapathi

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