Mar 9, 2004

PNA Technology

Molecular Biotechnology
Peter E Nielsen

Abstract

Peptide nucleic acids (PNA) are deoxyribonucleic acid (DNA) mimics with a pseudopeptide backbone. PNA is an extremely good structural mimic of DNA (or of ribonucleic acid [RNA]), and PNA oligomers are able to form very stable duplex structures with Watson-Crick complementary DNA and RNA (or PNA) oligomers, and they can also bind to targets in duplex DNA by helix invasion. Therefore, these molecules are of interest in many areas of chemistry, biology, and medicine, including drug discovery, genetic diagnostics, molecular recognition, and the origin of life. Recent progress in studies of PNA properties and applications is reviewed.

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Mentioned in this Paper

Peptide Nucleic Acids
Molecular Helix
Bacteriocidal Agents
Helix (Snails)
Neurofibromatosis 1
Antisense Probes
Mimic brand of tebufenozide
Hydrogen Bonding
DNA, Complementary
Helix of Ear

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