Pneumatosis Intestinalis in COVID-19: Case Series

Curēus
Kelvin WongGulrukh Zaidi

Abstract

To describe the clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) who developed pneumatosis intestinalis (PI). This case series was conducted in intensive care units at two large tertiary care centers within the Northwell Health System, located in New York State. Patients were included if they were identified as having confirmed COVID-19 as well as pneumatosis intestinalis from March 16, 2020 to July 31, 2020. Patient demographics, clinical characteristics, vasopressor use, anticoagulation use, opiate use, paralytic use, COVID-19 treatment regimen, serum lactate, arterial pH, serum bicarbonate, subsequent intervention, and outcomes during hospitalization were collected.  Results: A total of nine patients were identified. Average serum lactate was 4.33 mmol/L at time of diagnosis. Portal venous gas (56%) and bowel dilation (56%) were common radiographic findings. Subsequent morbidity (increased vasopressor requirements - 67%, acute kidney injury - 67%, increased oxygen requirements - 44%) and mortality (78%) were high. PI occurred despite a majority of patients being on anticoagulation (78%). Interleukin-6 (IL-6) inhibitors were commonly administered (56%) prior to development of PI. Pneu...Continue Reading

References

Sep 3, 2011·Arthritis Research & Therapy·Michael H SchiffRonald F van Vollenhoven
Jun 20, 2013·The Journal of Trauma and Acute Care Surgery·Joseph J DuBoseUNKNOWN EAST Pneumatosis Study Group
Apr 24, 2020·Lancet·Zsuzsanna VargaHolger Moch
May 12, 2020·Radiology·Rajesh BhayanaAvinash Kambadakone
Jun 6, 2020·International Journal of Legal Medicine·Carolin EdlerJan-Peter Sperhake
Jul 2, 2020·Curēus·Anupam K GuptaMiguel Lopez-Viego

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Citations

Mar 9, 2021·Frontiers in Medicine·Diogo Alpuim CostaJoão Vieira Branco

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Methods Mentioned

BETA
sedation

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