Pneumatosis intestinalis in COVID-19

BMJ Open Gastroenterology
Simone MeiniFiorella Piani

Abstract

COVID-19 is a respiratory illness due to novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), described in December 2019 in Wuhan (China) and rapidly evolved into a pandemic. Gastrointestinal (GI) tract can also be involved. A 44-year-old man was hospitalised for COVID-19-associated pneumonia. A rapid recovery of respiratory and general symptoms was observed after 1 week of treatment with lopinavir/ritonavir plus hydroxychloroquine and broad-spectrum antibiotics (piperacillin-tazobactam plus teicoplanin). No GI symptoms were reported during hospitalisation, but a lung contrast-enhancement CT (CE-CT) excluding thromboembolism showed, as collateral finding, intraperitoneal free bubbles not present on a previous CT examination; the subsequent abdominal CE-CT described pneumatosis intestinalis (PI) involving the caecum and the right colon. Ciprofloxacin plus metronidazole was started, and the 2-week follow-up CT showed the complete resolution of PI. The pathogenesis of PI is poorly understood. PI involving the caecum and right colon has been described for HIV and Cytomegalovirus infections, but, to our best knowledge, never before in COVID-19. We hypothesise a multifactorial aetiopathogenesis for PI, with a possible ...Continue Reading

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Citations

Sep 10, 2020·BMJ Case Reports·Paige AielloShakir Hussein
Nov 15, 2020·Journal of Clinical Medicine·Keiichi MitsuyamaSatoshi Matsumoto
Nov 15, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Wesam Hassan, Haidi Karam-Allah Ramadan
Feb 27, 2021·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Paula Pérez NaranjoLaura Férnandez Navarro
Aug 23, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Sonia Villapol
Jun 3, 2021·Pharmaceutics·Kevin McCoyCassie S Mitchell
Jun 22, 2021·Frontiers in Medicine·Santiago J MiyaraErnesto P Molmenti
Aug 13, 2021·BJR Open·Damiano CarusoAndrea Laghi
Aug 18, 2021·BMJ Case Reports·Nada F MustafaShinil K Shah
Aug 27, 2021·Signal Transduction and Targeted Therapy·Zirui MengBinwu Ying
Jan 13, 2022·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Marcelo Augusto Fontenelle Ribeiro-JuniorPaola Rezende Néder

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