PMID: 7940425Sep 1, 1994Paper

Pneumococcal antigen detection in bronchoalveolar lavage fluid from patients with pneumonia

Thorax
P JiménezM Velásquez

Abstract

Pneumococcal pneumonia can be diagnosed by the detection of capsular antigen in sputum, serum, pleural fluid, or urine using countercurrent immunoelectrophoresis and latex agglutination. In addition, quantitative cultures of bronchoalveolar lavage (BAL) fluid are also reliable for establishing the aetiology of pneumonia. This study investigated the value of rapid detection of pneumococcal antigen in BAL fluid from patients with pneumonia. Pneumococcal antigen was detected by countercurrent immunoelectrophoresis and latex agglutination. Patients were grouped according to BAL quantitative culture results into pneumococcal pneumonia (n = 24), other known aetiology (n = 18), and unknown aetiology (n = 17). Thirteen patients with interstitial lung disease and without pneumonia served as a control group. In patients with pneumococcal pneumonia, antigen was detected by countercurrent immunoelectrophoresis in 50% and by latex agglutination in 54% of cases. In patients with pneumonia of unknown aetiology pneumococcal antigen was detected by latex agglutination in 53% of cases. Antigen was not detected in patients with pneumonia of other known aetiology or in control patients, yielding a specificity of 100%. In patients with pneumococcal...Continue Reading

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Citations

Sep 24, 1999·Pediatric Pulmonology·V P McCarthyM A Lucas
Apr 1, 1997·Respiratory Medicine·A Ruiz-GonzálezM Rubio-Caballero
Aug 7, 2001·Journal of Immunoassay & Immunochemistry·M D Cima-CabalJ R de los Toyos
Nov 18, 2005·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Daniel GennéReto Lienhard

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